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  • Disulphide bond formation is essential for vaccinia virus late protein L1R function and for production of infectious progeny

    Creator:
    Blouch, Robert Edward
    Abstract:
    L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
    Resource Type:
    Masters Thesis
    Full Text:
    ................................................ 18 4. RESULTS ................................................................. 20 Characterization

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation
    Full Text:
    also harvested after 4 to 5 h of growth (transition from logarithmic to stationary phase). 27

  • A Genome-Wide, Phenotypic Screen for Genes Regulating Quorum Sensing in Pseudomonas aeruginosa

    Creator:
    Gobble, Timothy Robert
    Abstract:
    The opportunistic pathogen Pseudomonas aeruginosa possesses two LuxR-LuxI type quorum-sensing systems that use diffusible acyl-homoserine lactone molecules to autoinduce and coordinate expression of multiple virulence factors. We conducted a highthroughput screen for mutants deficient in skim-milk proteolysis—a quorum-sensing dependent phenotype—using a nonredundant transposon-insertion library representing most nonessential genes in P....
    Resource Type:
    Honors College Thesis
    Full Text:
    global regulatory networks 4 2 High-throughput screen for skim-milk proteolysis 13 3 Gel

  • Characterization of Baculovirus genes involved in genome replication and processing

    Creator:
    Vanarsdall, Adam L.
    Abstract:
    The Baculoviridae comprise a diverse group of occluded DNA viruses that contain large double-stranded DNA genomes of 80 - 180 kb and may encode up to 180 gene products. To understand how baculoviruses replicate and process their genomes and the gene products that are involved in these events, a series...
    Resource Type:
    Dissertation
    Full Text:
    production. 4  Copyright by Adam L. Vanarsdall

  • Identification and analysis of vaccinia virus acylproteins

    Creator:
    Hansen, Scott G.
    Abstract:
    Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
    Resource Type:
    Dissertation
    Full Text:
    % of the protein-bound myristate was rapidly (<4 h) elongated to palmitate in these cells, and the