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Filtering by: Creator Hellickson, Martin L. Remove constraint Creator: Hellickson, Martin L. Degree Field Microbiology Remove constraint Degree Field: Microbiology

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  • Evolution of a streamlined cooperator in Pseudomonas aeruginosa quorum sensing

    Creator:
    Huie, Jessica L.
    Abstract:
    Social behavior leading to the production of common goods is prone to exploitation. One such behavior in Pseudomonas aeruginosa is quorum sensing (QS), by which the bacteria produce signals to regulate extracellular common goods. Exploitation comes in the form of cheaters which have a mutation in the central quorum sensing...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF Jessica L. Huie for the degree of Master of Science in Microbiology

  • Social Evolution and Regulatory Architecture of Pseudomonas aeruginosa Quorum Sensing

    Creator:
    Asfahl, Kyle L.
    Abstract:
    Cell-cell communication in bacteria is understood to facilitate the coordination of population-wide cooperative behavior in the form of concerted gene expression. The opportunistic pathogen Pseudomonas aeruginosa uses such a communication mechanism to regulate a large group of genes important to virulence strategies in this bacterium. This general mechanism of communication...
    Resource Type:
    Dissertation
    Full Text:
    SOCIAL INTERACTIONS IN BACTERIAL CELL-CELL SIGNALING Kyle L. Asfahl and Martin Schuster

  • Studies on the evolution and expression of the Type II ferripyoverdine receptor gene fpvAIIb in Pseudomonas aeruginosa

    Creator:
    Glover, Rochelle
    Abstract:
    When iron levels are low, the opportunistic pathogen Pseudomonas aeruginosa secretes the high-affinity iron-binding siderophore pyoverdine. The cognate ferripyoverdine receptor, FpvA, has gained attention as the most divergent gene in the organism’s genome, showing substantial evidence of positive selection. S-type pyocins, bacteriocins with specificity to Pseudomonads, enter cells through FpvA...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________ Martin Schuster When

  • Characterization of Quorum-Sensing Diversity in Environmental Pseudomonas aeruginosa Populations

    Creator:
    Grellmann, Elise Kaylene
    Abstract:
    While the quorum-sensing (QS) diversity of the opportunistic pathogen Pseudomonas aeruginosa has been well established in cystic fibrosis (CF) lung infections and in vitro experiments, little is known about its QS-diversity in natural environments. One significant QS-deficient behavior is social cheating. Social cheaters contain mutations that prevent them from producing...
    Resource Type:
    Honors College Thesis
    Full Text:
    aeruginosa Populations. Abstract approved: Martin Schuster While the quorum-sensing (QS

  • Quorum sensing gene regulation in Pseudomonas aeruginosa

    Creator:
    Gupta, Rashmi
    Abstract:
    Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
    Resource Type:
    Dissertation
    Full Text:
    : Quorum Sensing Gene Regulation in Pseudomonas aeruginosa. Abstract approved: Martin Schuster

  • The Fitness Costs and Regulatory Strategies of Cooperative Siderophore Production in Pseudomonas

    Creator:
    Sexton, David
    Abstract:
    Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: Martin Schuster Cooperative behaviors in bacteria are increasingly

  • Strain construction to test the significance of antiactivation in Pseudomonas quorum sensing

    Creator:
    Goff, Shannon Elise
    Abstract:
    The quorum sensing regulatory pathway has been extensively studied for its impact on the virulence of Pseudomonas aeruginosa, an opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals such as those suffering from the genetic disorder cystic fibrosis. Part of the quorum sensing pathway that has not been...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: Martin Schuster The quorum sensing regulatory pathway has been extensively studied

  • The Social Interactions of Pseudomonas aeruginosa

    Creator:
    Smith, Parker
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Martin Schuster Pseudomonas aeruginosa is a ubiquitous environmental microbe

  • Study on the Evolution and Expression of the Pyoverdine Receptor FpvA inPseudomonas aeruginosa

    Creator:
    Singh, Amandip
    Abstract:
    Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium that is capable of causing infections in people who are immune compromised. The bacterium can live in a variety of environments due to the variety of virulence factors it can produce. It is well adapted to living in iron-stringent conditions because it can...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Martin Schuster Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium that is

  • Cooperation and conflict in Pseudomonas aeruginosa quorum sensing

    Creator:
    Wilder, Cara N.
    Abstract:
    Pseudomonas aeruginosa is an environmental bacterium as well as an opportunistic pathogen that primarily infects immunocompromised individuals, including those suffering from cystic fibrosis. The density-dependent regulation of gene expression via cell-to-cell communication, also termed quorum sensing (QS), is an important virulence determinant in this organism. Generally, P. aeruginosa uses three...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________________________ Martin Schuster Pseudomonas aeruginosa is an environmental bacterium as well as an