Microbial activity within elevated CO2 and oxygen depleted environments changes with
density driven stratification overturn in the seasonally anoxic region of Devil’s Hole,
Bermuda. The temperature gradient developed during the summer months creates a
natural laboratory to study bacterial and virus population density and microbial
community dynamics in the anoxic...
Over 100 monthly bacterioplankton DNA samples, from each of the surface and 200 m depths at the Bermuda Atlantic Time-series Study (BATS) site, were analyzed for community assembly processes. Correlation networks, filtered for potential autocorrelation artifacts, were constructed for each depth. Network characteristics for the two depths were remarkably similar...
The Chlamydiaceae are a family of obligate intracellular bacteria with a unique biphasic developmental cycle. The replicating, metabolically active, intracellular phase bacteria (RBs) grow within a cellular vacuole know as the inclusion. Since the proteins the Chlamydiaceae secrete into this membrane are the means of host/parasite interaction, they have long...
The Sortase A (SrtA) enzyme is a potential target for a new class of anti-infective drugs
because it is responsible for anchoring virulence factors to the surface of pathogenic,
Gram-positive bacteria such as Staphylococcus aureus. High throughput screening
yielded low molecular weight compounds that inhibit purified SrtA from S. aureus....
High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
Streptococcus gordonii is a bacterial species that naturally colonizes the oral cavity of most healthy humans. It resides in the mouth as an adherent to dental surfaces and, with few exceptions, does not cause disease in individuals it inhabits. It possesses qualities that encourage its use as a vector to...
The microsporidian parasite, Pseudoloma neurophilia, is the most commonly diagnosed infectious disease in laboratory populations of the zebrafish, Danio rerio. Infections by P. neurophilia are generally subclinical, however, they can become acute either incidentally or due to experimental immune suppression. Non-protocol induced variation can confound results in laboratory experiments using...
In host-associated microbiomes, the mechanisms that regulate community composition or the principles that govern dynamics remain far from clear. However, understanding how the structure of microbial communities shift as the system moves away from a healthy state is critical to assessing disease progression and to formulate any potential mitigation strategy....