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Filtering by: Creator Muehlbauer, Jeffrey D. Remove constraint Creator: Muehlbauer, Jeffrey D. Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

    Creator:
    Miller, Galen W.
    Abstract:
    Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
    Resource Type:
    Dissertation
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    direction in life, for which I cannot thank her enough. My dad, Jeffrey Miller, has helped get me where I

  • Using Culture-independent Genomics as a Means for Understanding Chlamydial Biology

    Creator:
    Putman, Timothy E.
    Abstract:
    The chlamydiae are a family of obligate intracellular bacteria that have a unique bi-phasic developmental cycle, unique cellular properties, and a unique set of challenges to studying its biology. While genetic manipulation is becoming routine in Chlamydia, there are significant challenges to working with this intracellular parasite. The body of...
    Resource Type:
    Dissertation
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     approved:  ______________________________________________________   Daniel  D.  Rockey

  • Understanding chlamydial biology through genome sequencing and comparative genomics

    Creator:
    Jeffrey, Brendan
    Abstract:
    The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
    Resource Type:
    Dissertation
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    Chapter 1: Brendan M. Jeffrey and Dan D. Rockey wrote the manuscript. Chapter 2: Robert J. Suchland

  • Transcriptomic analysis using high-throughput sequencing and DNA microarrays

    Creator:
    Fox, Samuel E.
    Abstract:
    Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
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    Dissertation
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    R. Christie, Henry D. Priest and Doug W. Bryant analyzed the data. Samuel E. Fox, Mark R. Christie

  • Transcriptomic Analyses of Crop Plants using Next-Generation Sequencing Technology

    Creator:
    Geniza, Matthew J.
    Abstract:
    Advancements in molecular biology and computer science have enabled researchers the ability to investigate the transcriptome – the quantification of an organism’s RNA transcripts in response to its environment on a system wide scale. The collective chapters of this thesis utilize high-throughput RNA sequencing, which produces hundreds of millions of...
    Resource Type:
    Dissertation
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    with Samuel E. Fox, Mamatha Hanumappa, Vijay K. Tiwari, and Jeffrey Leonard conceived the study

  • The Analysis of Hormone-dependent Transcription Factors and lncRNAs in Seeds by RNA Sequencing

    Creator:
    Sall, Khadidiatou
    Abstract:
    Seed dormancy is defined as the inability of viable seeds to germinate under conditionsotherwise favorable for germination. Dormancy provides a strategy for seeds to germinateat an appropriate time. Abscisic acid (ABA) is a major hormone involved in the regulationof seed dormancy. To elucidate the molecular mechanisms of dormancy, the twoexperimental...
    Resource Type:
    Dissertation
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    -chloro-3-indolylb-D-glucuronide-cyclohexylamine salt Xist X-inactive specific transcript

  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
    Resource Type:
    Dissertation

  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
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    Dissertation
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    , -D. VEGF-R expression can be induced by many cytokines and growth factors including IL-1, IL-6

  • Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

    Creator:
    Zhang, Yong
    Abstract:
    Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
    Resource Type:
    Dissertation
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    thanks to the rest of my committee, Dr. Jeffrey Greenwood, Dr. Mark Leid, Dr. Michael Schimerlik, Dr

  • Regulation by male-specific fruitless of neural circuitry used during courtship and copulation behavior in Drosophila melanogaster

    Creator:
    Latham, Kristin Lynn
    Abstract:
    Courtship and copulation behaviors in Drosophila melanogaster males are regulated by sex-specific products from the gene fruitless (fru). Male-specific FRU proteins (FRU[superscript M]) are putative transcription factors of the BTB-ZnF family that likely act by controlling development and maintenance of the neural circuitry used during male sexual behavior. However, which...
    Resource Type:
    Dissertation
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    action of the columnar genes, which specify dorsal-ventral (D-V) position, and the segment-polarity