Index Catalog // ScholarsArchive@OSU

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Creator:: Bednar, Riley M.
Abstract:: Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
Resource Type:: Dissertation

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Creator:: Lattier, Vera C.
Abstract:: Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
Resource Type:: Dissertation

Prostate cancer prevention with broccoli : from cellular to human studies

Creator:: Clarke, John D.
Abstract:: Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Resource Type:: Dissertation

Functional Characterization and Classification of Genes Essential to Flower Induction, Flower Development, and Seed Development in Populus and Eucalyptus

Creator:: Elorriaga, Estefania
Abstract:: This dissertation consists of four studies of Populus and Eucalyptus biotechnology and genomic science: 1) induction of floral sterility by tapetal expression of the ribonuclease Barnase in Populus; 2) CRISPR Cas9-mediated gene editing targeting LEAFY (LFY) and AGAMOUS (AG) homologs in Populus; 3) induction of floral sterility by CRISPR Cas9...
Resource Type:: Dissertation

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Creator:: Zamzow, Daniel R.
Abstract:: Memory is essential to everyday life. As we age, deficits in memory become apparent. The toll of age-related cognitive impairment can be devastating to families and costly to society. The NMDA receptor is a molecule in the brain that is instrumental in the formation of memories. The receptor is particularly...
Resource Type:: Dissertation

Regulation of antibiotic production and stress response by the biological control organism Pseudomonas fluorescens Pf-5

Creator:: Whistler, Cheryl A.
Resource Type:: Dissertation

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

Creator:: Chen, Cheng-Yao
Abstract:: PCR-based codon-specific random mutagenesis and site-specific mutagenesis were performed to construct a library of 18 amino acid changes at Arg276 in the conserved leucine-loop of the core catalytic domain of human uracil-DNA glycosylase (UNG). Each Arg276 mutant was then overproduced in E. coli cells and purified to apparent homogeneity by...
Resource Type:: Dissertation

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: RNA metabolism (Fu et al., 2007). The number of T3Es in a pathogen’s arsenal ranges from as few as

ScholarsArchive@OSU

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Prostate cancer prevention with broccoli : from cellular to human studies

Functional Characterization and Classification of Genes Essential to Flower Induction, Flower Development, and Seed Development in Populus and Eucalyptus

Mechanisms that influence the posttranslational modification of the GluN2B subunit in the aged brain

Regulation of antibiotic production and stress response by the biological control organism Pseudomonas fluorescens Pf-5

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

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