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Filtering by: Creator Maier, Claudia Remove constraint Creator: Maier, Claudia Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology Language English [eng] Remove constraint Language: English [eng]

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  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
    Resource Type:
    Dissertation
    Full Text:
    . David Williams and Dr. Claudia Maier. Thank you for all of your advice and suggestions. You played

  • Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

    Creator:
    Zhang, Yong
    Abstract:
    Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
    Resource Type:
    Dissertation
    Full Text:
    . Paul Murtaugh, Dr. Claudia Maier and Dr. Lan Xue for their invaluable support and feedback during

  • Transcriptional networks controlled by the fatty acid regulators FAR-1 and FAR-2

    Creator:
    Bredeweg, Erin L.
    Abstract:
    Fungi are capable of growth on a wide variety of carbon sources, both living and dead. They can produce an arsenal of enzymes and transporters for harvesting sugars, polysaccharides, amino acids, lipids and micronutrients from their environments [1]. Within the nucleus of a cell, transcription factors (TF) control whether genes...
    Resource Type:
    Dissertation
    Full Text:
    ! Fowler,!Dr.!Claudia!Maier,!and!Dr.!Christine!Kelly!for!their!time!and!input!during!the! process!of

  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    . Maier, and Dr. Rockey for their guidance and assistance throughout my graduate studies. I would like

  • The Response to Sulforaphane in Metastatic Prostate Cancer Cells

    Creator:
    Watson, Gregory
    Abstract:
    Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
    Resource Type:
    Dissertation
    Full Text:
    Wickramasekara and Dr. Claudia Maier for their contribution to my dissertation work. I am very thankful that

  • Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

    Creator:
    McNamara, Michael J.
    Abstract:
    Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
    Resource Type:
    Dissertation
    Full Text:
    for M. avium. Shin-Cheng Tzeng, Li Zhang, Claudia Maier and Luiz Bermudez assisted with