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Filtering by: Creator Brodersen, C.M. Remove constraint Creator: Brodersen, C.M. Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Processing and functional diversity of plant microRNA

    Creator:
    Cuperus, Josh
    Abstract:
    RNA interference pathways can involve amplification of secondary siRNAs by RNA-dependent RNA polymerases. In plants, RDR6-dependent secondary siRNAs, including transacting siRNAs (tasiRNAs), arise from transcripts targeted by some microRNAs (miRNAs). In the case of TAS3 tasiRNA formation, ARGONAUTE7 (AGO7)-miR390 complexes interact with primary transcripts at two sites, resulting in recruitment...
    Resource Type:
    Dissertation
    Full Text:
    ; Brodersen et al., 2008; Dugas and Bartel, 2008). Furthermore, the extent to which both mechanisms act may

  • Origins and evolution of plant microRNA genes

    Creator:
    Fahlgren, Noah
    Abstract:
    Eukaryotic small RNA (~20-30 nucleotides) are diverse regulatory molecules that repress gene expression at the transcriptional and post-transcriptional levels, defend hosts against invading viruses and defend genomes against selfish DNA elements. Small RNA populations are studied by high-throughput sequencing of the total small RNA fraction isolated from cells, however, the...
    Resource Type:
    Dissertation
    Full Text:
    translation initiation or elongation (Brodersen et al., 2008; Lanet et al., 2009). Animal miRNA are

  • Endogenous and antiviral RNA silencing pathways in Arabidopsis

    Creator:
    Chapman, Elisabeth J.
    Abstract:
    RNA silencing pathways are required for a wide variety of processes in most eucaryotes. In plants, small-interfering RNA (siRNA) arising from transposons and other repetitive sequences is associated with heterochromatin formation and maintenance. MicroRNAs and trans-acting siRNAs encoded at discrete loci function as negative regulators of gene expression by triggering...
    Resource Type:
    Dissertation