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Filtering by: Creator Hanan, Barry B. Remove constraint Creator: Hanan, Barry B. Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology Rights Statement In Copyright Remove constraint Rights Statement: In Copyright Subject Bacterial genetics Remove constraint Subject: Bacterial genetics

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  • Understanding chlamydial biology through genome sequencing and comparative genomics

    Creator:
    Jeffrey, Brendan
    Abstract:
    The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
    Resource Type:
    Dissertation
    Full Text:
    trachoma (A, B, and C), and those associated with non-invasive urogenital disease (D through K) (51

  • Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

    Creator:
    Early, Julie V.
    Abstract:
    Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
    Resource Type:
    Dissertation
    Full Text:
    B, Bottone EJ. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of

  • Mechanisms for the interaction of environmental mycobacteria with host cells

    Creator:
    Harriff, Melanie J.
    Abstract:
    Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
    Resource Type:
    Dissertation
    Full Text:
    expression of genes in M. avium over- 44 expressing A) MAV_3679, or B) MAV_5138, compared to wild-type

  • Characterization of the genomic islands from tetracycline-resistant Chlamydia suis

    Creator:
    Dugan, Jae
    Abstract:
    Tetracycline (Tet)-resistant strains of Chlamydia suis were isolated from swine farms in the Midwest. The isolation of the resistant strains was significant because Tet is an antibiotic used to treat infections by veterinarians and doctors. One of the tetracycline (Tet)-resistant strains, R19, was able to survive in Tet up to...
    Resource Type:
    Dissertation
    Full Text:
    (43). The role of B-cells and antibody levels is unclear but studies show that they might be