Index Catalog // ScholarsArchive@OSU

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Creator:: Chatterjee, Paroma
Abstract:: Auditory defects and disorders are prevalent at all ages and affect 8% of the population in developed nations including newborns and children. Congenital hearing loss is the most common birth defect and it is estimated that 1 in 1000 children are affected by deafness at birth or before the onset...
Resource Type:: Dissertation

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation

Membrane receptors for steroid hormones : pursuing the identity of a membrane glucocorticoid receptor in an amphibian brain

Creator:: Evans, Simon J.
Abstract:: In addition to the well-characterized genomic mechanism of steroid action that uses intracellular receptors, steroid hormones also signal through nongenomic processes that use membrane receptors. A membrane receptor for corticosterone (CORT) has been described in brains of the roughskin newt (Taricha granulosa). This receptor is believed to be a G-protein...
Resource Type:: Dissertation
Full Text:: . Towle, A. C., and Sze, P. Y. (1983) J Steriod Biochem 18(2), 135-143 112. Fu, H., Guo, Z., and Chen

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: ; Jia et al., 2000; Krasileva et al., 2010). Evidence suggested an alternate mechanism for the action

Genomic Resource Development for European Hazelnut (Corylus avellana L.)

Creator:: Rowley, Erik R.
Abstract:: European hazelnut (Corylus avellana L.) is an important crop Oregon's Willamette Valley, producing 99% of the hazelnuts grown in North America and brings over US $60 million dollars to the region annually. Hazelnuts are rich in fiber and vitamins, as well in demand by consumers due to their popularity as...
Resource Type:: Dissertation

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Creator:: Bednar, Riley M.
Abstract:: Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
Resource Type:: Dissertation

Processing and functional diversity of plant microRNA

Creator:: Cuperus, Josh
Abstract:: RNA interference pathways can involve amplification of secondary siRNAs by RNA-dependent RNA polymerases. In plants, RDR6-dependent secondary siRNAs, including transacting siRNAs (tasiRNAs), arise from transcripts targeted by some microRNAs (miRNAs). In the case of TAS3 tasiRNA formation, ARGONAUTE7 (AGO7)-miR390 complexes interact with primary transcripts at two sites, resulting in recruitment...
Resource Type:: Dissertation

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

Creator:: Alto, Sarah I.
Abstract:: Skeletal muscles provide several functions, including, yet not limited to, voluntary body movement and locomotion, posture and body position, and soft tissue support. Skeletal muscles also play a role in metabolism, requiring energy to facilitate contraction. Each skeletal muscle serves a different purpose despite seeming to perform the same task....
Resource Type:: Dissertation

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Creator:: Manchanda, Aayushi
Abstract:: Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
Resource Type:: Dissertation

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Creator:: Early, Julie V.
Abstract:: Mycobacterium avium cause disseminated disease in immunocompromised people such as AIDS patients. Subsequent to crossing the intestinal epithelium, M. avium thrive within vacuoles in macrophages. The bacteria exhibit a different, more invasive, phenotype after being in macrophages compared to M. avium from laboratory conditions. We hypothesized that this intracellular phenotype...
Resource Type:: Dissertation

ScholarsArchive@OSU

Establishing Larval Zebrafish as an In Vivo Model Organism for Characterizing the Roles of Otoferlin, a Sensory Hair Cell Protein Essential for Hearing

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Membrane receptors for steroid hormones : pursuing the identity of a membrane glucocorticoid receptor in an amphibian brain

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Genomic Resource Development for European Hazelnut (Corylus avellana L.)

Exploring the Limits of Ligation Rate and Specificity in Protein Immobilization Using the Genetically Encoded Tetrazine Ligation

Processing and functional diversity of plant microRNA

Investigation of the Patterns and Transcriptional Regulators from Gene Expression Profiles of Adult Murine Soleus and Tibialis Anterior Skeletal Muscles

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Molecular and cellular characterization of the intracellular phenotype of Mycobacterium avium

Limit your search

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search