Index Catalog // ScholarsArchive@OSU

Regulation of skeletal muscle protein degradation by u-calpain and development of a skeletal muscle-specific inducible expression system

Creator:: Xiao, Ying-Yi
Abstract:: The first goal of this study was to understand the role of u-calpain in skeletal muscle protein degradation in cultured muscle cells. Several strategies were developed to down-regulate endogenous u-calpain activity and m-calpain activity in rat myotubes. These included over-expression of antisense u-calpain (AnsL), dominant negative u-calpain (DN-u-CL), antisense 30K...
Resource Type:: Dissertation
Full Text:: ., Zhou, Y., Wang, X., McMurtry J.P., Rosebrough, R.W., Decuypere, E., Buys, N., Darras, V.M., Van der

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation

Identification and characterization of type III effector proteins in plant-associated bacteria

Creator:: Thomas, William J.
Abstract:: Symbioses between microbes and multicellular eukaryotes are found in all biomes, and encompass a spectrum of symbiotic lifestyles that includes parasitism and disease, commensalism, and mutually beneficial interdependent host-microbe relationships. Regardless of outcome, these symbiotic lifestyles are governed by a complex molecular "courtship" between microbe and potential host. This courtship...
Resource Type:: Dissertation
Full Text:: (van Rhijn and Vanderleyden, 1995). The limited host range of rhizobia constitutes the first level

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: called avirulence (Avr) proteins (Flor, 1971; van der Biezen and Jones, 1998). Avr recognition is

Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora

Creator:: Halsey, Kimberly H.
Abstract:: Pseudomonas butanovora, Mycobacterium vaccae, and Nocardioides sp. CF8 utilize distinctly different butane monooxygenases (BMOs) to initiate degradation of recalcitrant chlorinated ethenes (CEs) that pollute aquifers and soils. BMO-dependent degradation of CEs such as trichloroethylene (TCE) can lead to cellular toxicities. The type and severity of TCE transformation-dependent damage can have...
Resource Type:: Dissertation
Full Text:: serves as a useful methane- surrogate because its van der Waals radius is about the same as methane

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:: Smith, Anthony R.
Abstract:: The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...
Resource Type:: Dissertation

Characterization of the LeIAA family of auxin-regulated genes in tomato (Lycopericon esculentum, Mill.)

Creator:: Nebenfuhr, Andreas
Abstract:: The plant hormone auxin regulates many aspects of plant growth and development. At the cellular level, auxin can stimulate cell division, cell elongation, and cell differentiation. Little is known about the molecular mechanisms that mediate auxin action at this level, although changes in gene expression have been implicated in each...
Resource Type:: Dissertation
Full Text:: , Takahashi et al., 1991), tobacco cell cultures (pCNT103, van der Zaal et al., 1987), and soybean

Interactions of auxin with ethylene and gravity in regulating growth and development in tomato (Lycopersicon esculentum, Mill.)

Creator:: Madlung, Andreas
Abstract:: Plant growth, development, and environmental responsiveness are dependent on hormone-induced gene expression. This dissertation reports multiple interactions between the plant hormones auxin and ethylene and investigates their contribution to the gravitropic response, elongation growth, adventitious root formation, callus and tracheary element initiation and growth, and flower development. Four mutants of...
Resource Type:: Dissertation
Full Text:: . Meredith Howell, Kari van Zee and Indira Rajagopal shared with me their skill and experience in teaching

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Creator:: McNamara, Michael J.
Abstract:: Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Resource Type:: Dissertation

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

Creator:: Zhang, Yong
Abstract:: Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization...
Resource Type:: Dissertation

ScholarsArchive@OSU

Regulation of skeletal muscle protein degradation by u-calpain and development of a skeletal muscle-specific inducible expression system

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Identification and characterization of type III effector proteins in plant-associated bacteria

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Investigating the basis of substrate specificity in butane monooxygenase and chlorinated ethene toxicity in Pseudomonas butanovora

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Characterization of the LeIAA family of auxin-regulated genes in tomato (Lycopericon esculentum, Mill.)

Interactions of auxin with ethylene and gravity in regulating growth and development in tomato (Lycopersicon esculentum, Mill.)

Surface-exposed proteins in the pathogenesis of Mycobacterium avium subsp. hominissuis

Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation

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