Index Catalog // ScholarsArchive@OSU

Genetic dissection of Victoria blight disease susceptibility in Arabidopsis thaliana

Creator:: Sweat, Teresa A.
Abstract:: The fungus Cochliobolus victoriae causes Victoria blight of oats and Arabidopsis and is pathogenic due to its production of a compound called victorin, which induces programmed cell death in sensitive plants. Victorin sensitivity in Arabidopsis is conferred by the dominant gene LOCUS ORCHESTRATING VICTORIN EFFECTS1 (LOV1), which encodes a coiled-coil-nucleotide...
Resource Type:: Dissertation
Full Text:: Arabidopsis thaliana. Abstract approved: Thomas J. Wolpert The fungus Cochliobolus

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

Creator:: Kimbrel, Jeffrey A.
Abstract:: Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
Resource Type:: Dissertation
Full Text:: fellow graduate students, particularly Sam Fox and Bill Thomas, who made the lows seem a little higher

In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

Creator:: Venkataraman, Anand
Abstract:: Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...
Resource Type:: Dissertation

Role of Melanocytic Vitamin D Receptor (VDR) in UVB-induced Melanocyte Homeostasisand Keratinocytic Retinoid–X-Receptor α (RXRα) in UVB Induced Melanomagenesis

Creator:: Chagani, Sharmeen
Abstract:: Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...
Resource Type:: Dissertation

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Creator:: Hyter, Stephen D.
Abstract:: Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
Resource Type:: Dissertation

16S rRNA Gene Amplicon Sequencing Reveals Trends in Marine Bacterial Diversity and Taxonomic Composition in Natural and Human-built Systems

Creator:: Morelan, Ian A.
Abstract:: Bacteria are abundant in marine environments. They play important roles in nutrient cycling and form symbiotic interactions with eukaryotes. However, the vast majority of bacterial taxa are difficult to maintain in laboratory cultures, meaning that most microbiological research of the past century has focused on a small subset of bacteria....
Resource Type:: Dissertation
Full Text:: , Thomas Sharpton, and Rebecca Vega Thurber helped conceive and design the study. Christopher Gaulke

The proteomic and transcriptomic responses to iron, sulfur, and nitrogen limitation in the abundant marine bacterium Candidatus Pelagibacter ubique

Creator:: Smith, Daniel P.
Abstract:: Batch cultures of Candidatus Pelagibacter ubique were grown under iron-, organosulfur-, and nitrogen-limiting conditions to understand how this ubiquitous marine bacterium responds to and interacts with environments where growth is limited by the availability of these nutrients. Global gene expression was monitored using microarrays and quantitative mass spectrometry to observe...
Resource Type:: Dissertation

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation

Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

Creator:: Noell, Stephen E.
Abstract:: Oligotrophic bacteria are adapted to low nutrient concentrations. As most of the ocean is oligotrophic (low in nutrients), oligotrophic bacteria thrive in the ocean and make up the majority of planktonic cells. Because of this, oligotrophs are crucial to oceanic nutrient cycles. However, marine oligotrophic bacteria are dwarfed by their...
Resource Type:: Dissertation

ScholarsArchive@OSU

Genetic dissection of Victoria blight disease susceptibility in Arabidopsis thaliana

Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

Role of Melanocytic Vitamin D Receptor (VDR) in UVB-induced Melanocyte Homeostasisand Keratinocytic Retinoid–X-Receptor α (RXRα) in UVB Induced Melanomagenesis

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

16S rRNA Gene Amplicon Sequencing Reveals Trends in Marine Bacterial Diversity and Taxonomic Composition in Natural and Human-built Systems

The proteomic and transcriptomic responses to iron, sulfur, and nitrogen limitation in the abundant marine bacterium Candidatus Pelagibacter ubique

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Outliers: The Unusual Characteristics of Marine Carbon-Oxidizing Bacterial Cells Adapted to Oligotrophic Conditions

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