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  • Molecular characterization and genetic recombination of snakehead rhabdovirus

    Creator:
    Johnson, Marc C.
    Abstract:
    The complete genome of snakehead rhabdovirus (SHRV) was cloned and molecularly characterized. This was initially accomplished through the sequence determination of its glycoprotein gene and the phylogenetic analysis of this gene with orthologous genes from other rhabdoviruses. The phylogenetic analysis revealed that SHRV groups with viruses of the genus Novirhabdovirus....
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    Dissertation
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    phylogenetic analysis of this gene with orthologous genes from other rhabdoviruses. The phylogenetic analysis

  • Endogenous and antiviral RNA silencing pathways in Arabidopsis

    Creator:
    Chapman, Elisabeth J.
    Abstract:
    RNA silencing pathways are required for a wide variety of processes in most eucaryotes. In plants, small-interfering RNA (siRNA) arising from transposons and other repetitive sequences is associated with heterochromatin formation and maintenance. MicroRNAs and trans-acting siRNAs encoded at discrete loci function as negative regulators of gene expression by triggering...
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    Dissertation
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    target genes are ascribed to only a fraction of these [20-22]. MIRNA genes and target gene families

  • Vaccinia virus I7L core protein proteinase

    Creator:
    Byrd, Chelsea M.
    Abstract:
    Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
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    Dissertation
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    ................................................................... 1 2. THE VACCINIA VIRUS I7L GENE PRODUCT IS THE CORE PROTEiN PROTEINASE

  • Complex architecture of a closterovirus virion

    Creator:
    Napuli, Alberto J.
    Abstract:
    In this investigation we examined the molecular architecture and functions associated with the virion components of the Beet yellows virus (BYV), family Closteroviridae. The BYV virions are filamentous particles composed of two coat proteins, the major coat protein (CP), which encapsidates the majority of the genome, and the minor coat...
    Resource Type:
    Dissertation

  • Origins and evolution of plant microRNA genes

    Creator:
    Fahlgren, Noah
    Abstract:
    Eukaryotic small RNA (~20-30 nucleotides) are diverse regulatory molecules that repress gene expression at the transcriptional and post-transcriptional levels, defend hosts against invading viruses and defend genomes against selfish DNA elements. Small RNA populations are studied by high-throughput sequencing of the total small RNA fraction isolated from cells, however, the...
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    Dissertation
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    presented on December 6, 2010. Title: Origins and Evolution of Plant MicroRNA Genes. Abstract

  • Genomic characterization of a novel leporid Herpes simplex virus

    Creator:
    Babra, Bobby A.
    Abstract:
    The viral family Herpesviridae consists of large double stranded DNA viruses including eight species that infect humans with varying pathology from benign rashes to cancerous cell transformation. From three subfamilies, alpha-, beta- and gammaherpes, the alphaherpes contains the genera iltovirus, mardivirus, varicellovirus and simplex, two of which, the human simplex...
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    Dissertation
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    core protein coding genes with notable variation in the IE gene, ICP34.5 (a neurovirulent factor), a

  • Fine structure of the virus genome in a marine filamentous brown algae, Feldmannia

    Creator:
    Lee, Amy M.
    Abstract:
    Viruses or viruslike particles of eukaryotic algae are ubiquitous in aquatic habitats, however, suprisingly little is known about them. The research presented here focused on one such virus which infects a multicellular filamentous brown alga of the genus Feldmannia. Although preliminary studies had been performed on the genome structure of...
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    Dissertation
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    early genes is found at the 3' end of the DNA polymerase gene. Phylogenetic analysis of the FsV DNA

  • Rainbow trout cystatin C : gene expression, heterologous production and characterization

    Creator:
    Li, Fugen
    Abstract:
    Rainbow trout cystatin C cDNA has been isolated from trout liver. The full-length cystatin cDNA (674 bp) included the 5'untranslated region and the polyadenylation signal sequence AATAAA in the 3' region. Translation of the cDNA defines 132 amino acid residues. Comparison of the amino acid sequence with those of family...
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    Dissertation
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    cystatin C gene share several features with those housekeeping genes. The 5'-flanking region of the

  • Palmitylation of vaccinia virus proteins : identification of modification sites and biological relevance

    Creator:
    Grosenbach, Douglas W.
    Abstract:
    Vaccinia virus encodes at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through thioester linkage to cysteine residues. This is referred to as palmitylation of proteins. The purpose of this work was to gain an understanding of palmitylation, focusing on what defined...
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    Dissertation
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    taken to identify the genes in vaccinia virus that encode these proteins. We found that vaccinia virus

  • Characterization of the response mediated by the plant disease susceptibility gene LOV1

    Creator:
    Gilbert, Brian M.
    Abstract:
    Victoria blight, caused by fungus Cochliobolus victoriae, is a disease originally described on oats and recapitulated on Arabidopsis. Victoria blight is used as a model plant disease that conforms to an inverse gene-for-gene interaction. C. victoriae virulence is dependent upon its production of victorin, a host-specific toxin that induces programmed...
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    Dissertation
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    was twofold. Virus-induced gene silencing (VIGS) was employed to identify genes involved in