In a search for new therapeutic agents, a series of Mannich bases
derived from the following 2-phenylindolizines were prepared: 2-phenylindolizine, 1, 2-diphenylindolizine, 3-methyl-2-phenylindolizine,
3-ethyl-2-phenylindolizine, and 1-(2-hydroxyethyl)-2-phenylindolizine.
The investigation was based on the speculation that indolizine
analogs of physiologically active indoles might be useful medicinally.
A certain group of indoles, all...
In a two part thesis, studies were made of two
different types of structure-activity relationships.
The first part consists of the synthesis and biological
evaluation of a number of 4-substituted pyrazoles and
isoxazoles as inhibitors of liver alcohol dehydrogenase.
In an effort to better define the steric and electronic
effects...
A species of Ephedra found in southeastern Oregon,
identified as Ephedra viridis Coville is reported of medicinal
value among the American Indian tribes and other
dwellers of that locality in various affections such as
venereal diseases, kidney and bladder disturbances, in
stomach ulcers and abdominal pains, in delayed menstruation,
as...