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Filtering by: DOI 10.1172/JCI62070 Remove constraint DOI: 10.1172/JCI62070 Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Creator:

Baarda, Benjamin I.

Abstract:

Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...

Resource Type:

Dissertation
Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:

Carpenter, Evan L.

Abstract:

Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...

Resource Type:

Dissertation
Non-viral Vectors for Ocular Gene Delivery

Creator:

Herrera-Barerra, Marco, F.

Abstract:

Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...

Resource Type:

Dissertation
Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:

Kim, Jeonghwan

Abstract:

Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...

Resource Type:

Dissertation
Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:

Wan, Xuemei

Abstract:

Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...

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Dissertation

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Academic Affiliation

College of Pharmacy5

Advisor

Sahay, Gaurav2
Indra, Arup K.1
Ishmael, Jane E.1
Sikora, Aleksandra E.1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2018 to 2022

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Committee Member

Sun, Conroy3
McPhail, Kerry2
Alani, Adam1
Bishop, Cecily1
Bishop, Cecily V.1
more Committee Members »

Creator

Baarda, Benjamin I.1
Carpenter, Evan L.1
Herrera Barerra, Marco, F.1
Kim, Jeonghwan1
Wan, Xuemei1

Contributor

Becker, Alyssa L.1
Cassidy, Pamela B.1
Chagani, Sharmeen1
Ganguli Indra, Gitali1
Indra, Aaryan1
more Contributors »

Date

Date range begin – Date range end

Current results range from 2018 to 2022

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Decade

2020-20293
2010-20192

Degree Field

Pharmaceutical Sciences[remove]5

Degree Level

Doctoral5

Degree Name

Doctor of Philosophy (Ph.D.)5

Language

English [eng]5

License

All rights reserved5

Peer Reviewed

No5

Resource Type

Dissertation5

Rights Statement

In Copyright5

Subject

Gene therapy1
Melanoma1
Messenger RNA1
Neisseria gonorrhoeae1
Vaccines1

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