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Filtering by: Alternative title ssim Circular of information no. 269 Remove constraint Alternative title ssim: Circular of information no. 269 Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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  • Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

    Creator:
    Nosal, Daniel Grzegorz
    Abstract:
    Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
    Resource Type:
    Dissertation
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    comparison of superwarfarin stereoisomer half-lives. No significant differences between stereoisomers of a

  • Identification of Cervical Cancer Key Regulators using Network Biology Approach

    Creator:
    Vyshenska, Dariia
    Abstract:
    Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
    Resource Type:
    Dissertation
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    first chapter, we provide information of the current knowledge on how local microbiome and

  • Natural Products Discovery from Unique Microbial Habitats

    Creator:
    Gallegos, David A.
    Abstract:
    Marine natural products possess an abundance of diverse chemical scaffolds with unique biological activities. By targeting unusual or unique microbial environments within varying marine ecologies we can continue to discover novel chemistry with potentially new molecular targets. The research presented here is focused on exploring unusual chemical ecologies and the...
    Resource Type:
    Dissertation
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    apparently contributes to a loss of some activity……………………………………………….269 Figure S3.109 Comparison of

  • Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

    Creator:
    Nazari, Mohamad
    Abstract:
    Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
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    Dissertation
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    ............................................................................................................ 77! ! ! ! TABLE OF CONTENTS (continued) Page 3.7! Supporting Information

  • Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

    Creator:
    Back, Daniel C.
    Abstract:
    Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
    Resource Type:
    Dissertation
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    AN ABSTRACT OF THE DISSERTATION OF Daniel C

  • Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

    Creator:
    Baarda, Benjamin I.
    Abstract:
    Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...
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    Dissertation
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    . Although Laz appeared to influence expression of the nitrite reductase AniA, no interaction between the

  • Investigation of Procyanidins Used in Botanical Dietary Supplements

    Creator:
    Rue, Emily A.
    Abstract:
    Polyphenolic compounds found in foods such as fruits, vegetables, legumes, nuts and grains, are an integral part of the human diet. Within polyphenols, proanthocyanidins are referred to as condensed tannins and encompass procyanidins, propelargonidins and prodelphinidins. Among these, procyanidins are the largest group. Recent interest in these compounds is related...
    Resource Type:
    Dissertation
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    pathways of RDA, HRF, and QM fission. The tandem mass spectra provided structural information about the

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
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    OF THE DISSERTATION OF Jeonghwan Kim for the degree of Doctor of Philosophy in Pharmaceutical

  • Gene Networks of the Skeletal Muscle Cell

    Creator:
    Singh, Arun J.
    Abstract:
    Skeletal muscle is the largest organ in the body by mass, comprising roughly 40% of total bodyweight in adults. It plays diverse and unique roles that include movement, locomotion, and support for posture and internal organs, among others. The structural foundation for all skeletal muscle in adults is formed early...
    Resource Type:
    Dissertation
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    dynamics. On a basic level diffusion flow methods assume that the flow of biological information within a

  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
    Resource Type:
    Dissertation
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    hand, possesses virtually no risk of genomic integration 10. Since mRNA does not require nuclear