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Filtering by: Creator Keller, Aimee A. Remove constraint Creator: Keller, Aimee A. Degree Field Pharmaceutical Sciences Remove constraint Degree Field: Pharmaceutical Sciences

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  • Identification of Cervical Cancer Key Regulators using Network Biology Approach

    Creator:
    Vyshenska, Dariia
    Abstract:
    Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
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    Dissertation
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    been identified as a source of upregulation for cervical cancer driver genes but cannot fully explain

  • Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

    Creator:
    Carpenter, Evan L.
    Abstract:
    Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
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    Dissertation
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    ., keratinocytes). However, melanocytes encounter a large burden of oxidative stress during this process, due to

  • Drug Discovery and Chemical Ecology Investigations of Specialized Metabolism in Tolypocladium and Paraisaria

    Creator:
    Tehan, Richard M.
    Abstract:
    Since the discovery of penicillin in 1928, the fungal kingdom has remained a fertile source for the discovery of new, biologically active, natural products. Further, as natural products continue to be discovered from fungi, a deeper understanding of the critical role of specialized metabolism in fungal ecology is afforded. The...
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    Dissertation
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    remained a fertile source for the discovery of new, biologically active, natural products. Further, as

  • Development of Novel Agents to Combat Tuberculosis and Malaria

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
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    vulnerable to the infection due to a weakened immune system. Moreover, the emergence of multi-drug

  • Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

    Creator:
    Wierzbicki, Igor H.
    Abstract:
    The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
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    Dissertation
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    pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the

  • Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

    Creator:
    Axton, Elizabeth R.
    Abstract:
    Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
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    : ____________________________________________________ Jan F. Stevens and Robert Tanguay Nitric oxide (NO) is a signaling molecule that regulates

  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
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    Dissertation
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    -pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called

  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
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    this thesis, we study subcellular barriers to LNP-delivered mRNA and screen a unique class of