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Filtering by: Degree Field Pharmacology and Toxicology Subject Rats

The effects of the carcinostatic compound 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on the hepatic microsomal enzyme systems in rats

Creator:

Lu, Irene

Abstract:

Preliminary toxicity studies of BCNU in rats revealed that significant prolongations of pentobarbital hypnosis were associated with all doses employed. Investigations were undertaken to determine the underlying mechanism responsible for this observed effect. Studies on the in vitro metabolism of pentobarbital by hepatic microsomes of BCNU-treated animals demonstrated that significant...

Resource Type:

Dissertation
Potentiation of acute carbon tetrachloride hepatotoxicity by dietary exposure to chlorophenothane (DDT) in rats

Creator:

Koeferl, Michael Tallyn

Abstract:

There has been no toxicologic proof that the long-term, low-level exposure of man to chlorophenothane (DDT) is linked with an increased susceptibility to toxicity or disease. Acute pretreatment of rats with 75-100 mg/kg DDT has been demonstrated to potentiate CCI₄-induced hepatotoxicity in that species (McLean and McLean, 1966). Since the...

Resource Type:

Dissertation
The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Creator:

Giese, Neill Alan

Resource Type:

Masters Thesis