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Filtering by: Creator Fandrem, Richard Lee Degree Field Pharmacology and Toxicology

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Creator:

Hult, Richard Lee

Abstract:

An enhancement of the therapeutic effect and/or a reduction in the toxicity have been shown by a variety of antineoplastic compounds when glucose is added to the treatment schedule. A possible explanation for this involves a selective change in intracellular pH of the tumor tissue initiating a greater uptake of...

Resource Type:

Masters Thesis

Full Text:

AN ABSTRACT OF THE THESIS OF RICHARD LEE HULT for the degree
Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Creator:

Hult, Richard Lee

Abstract:

The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...

Resource Type:

Dissertation

Full Text:

by selected experimental tumors AN ABSTRACT OF THE THESIS OF RICHARD LEE HULT for the degree of