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Filtering by: Committee Member O'Neill, J. Philip Remove constraint Committee Member: O'Neill, J. Philip Degree Field Pharmacy Remove constraint Degree Field: Pharmacy Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

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  • Advanced studies on cyclic amino acids in neurological signaling and peptide antibiotics

    Creator:
    Blanchard, David, L.
    Abstract:
    L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in many organisms, including primates, as an intermediate in lysine degradation. The pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate oxidase (L-PO), and appears to be tissue specific to the central nervous system...
    Resource Type:
    Dissertation
    Full Text:
    : Dr. Philip Proteau, Dr. Taifo Mahmud, Dr. Xihou Yin, and Dr. Thomas Savage for their proofreading

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    N S H N H O OH O O N N NH2 NH2 S H2N O O NH2 S H2N O O Figure 1.1 A) Structure of