Index Catalog // ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: physiological availability from solid dosage forms are largely dependent upon having the drug in the dissolved

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Creator:: Tavipatana, Wattanaporn
Abstract:: Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
Resource Type:: Masters Thesis
Full Text:: has no significant effect on the pharmacokinetic behavior of theophylline, including protein or

Purine nucleotide-induced seizures in rat prepiriform cortex

Creator:: Zhao, Xiaoqin S.
Resource Type:: Masters Thesis
Full Text:: anticonvulsant effect of 2 methylthio-ATP is therefore likely to be due to its breakdown to 2-methylthio

Adenosine receptor modulation of seizure susceptibility in rats

Creator:: Szot, Patricia
Abstract:: Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
Resource Type:: Dissertation
Full Text:: observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: conceivable that this difference in physiological effect would be magnified during glucose peak

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Creator:: Leid, Mark
Abstract:: Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
Resource Type:: Dissertation
Full Text:: I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Creator:: Devaud, Leslie L.
Resource Type:: Dissertation
Full Text:: ]Ro5-4864 binding to rat olfactory bulb membranes: effect of cismethrin. 16. Schild plot of

Modulation of sensory afferent processing by endogenous spinal adenosine

Creator:: Keil, Gary J.
Resource Type:: Dissertation
Full Text:: independent systems to achieve a common physiological or 10 pharmacological effect. A number of

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Creator:: Zhang, Ge
Abstract:: Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...
Resource Type:: Masters Thesis
Full Text:: rank order potency, degree of stereoselectivity for R-PIA vs S-PIA and lack of anticonvulsant effect

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Creator:: Zhang, Ge, 1956-
Resource Type:: Dissertation
Full Text:: ; and the anticonvulsant effect of NECA was completely abolished by the adenosine receptor antagonist 8

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Creator:: Taur, Jan-Shiang
Abstract:: The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...
Resource Type:: Dissertation
Full Text:: inhibiting the drug efflux transporters. However, the effect of dietary flavonoids in the absorption of

Elimination of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid when normalized to urinary creatinine

Creator:: Beardsley, Grant D.
Resource Type:: Masters Thesis
Full Text:: anticonvulsant effect of delta-9-tetrahydrocannabinol and cannabidiol. Res. Comm. Chem. Path. Pharmacol. 9:23-39

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Creator:: Deffo, Tamboue Esaie
Abstract:: In an effort to isolate and characterize cardiac glycosides C-17 binding site(s), we have synthesized different affinity and photoaffinity C-17 side chain probes. These probes were screened for their ability to inhibit Na⁺,K⁺-ATPase enzyme, a pharmacological receptor of cardiac glycosides. The enzyme was isolated from hog kidney. Screening of these...
Resource Type:: Dissertation
Full Text:: , and Conformation ---Effect on Inotropic Activity 163 I. Introduction 164 II. Results and Discussion

Modification of the acute effects of ethanol or acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo

Creator:: LaFollette, Sharron E.
Abstract:: The inhibition of mixed-function oxidase (MFO) activity by ethanol or acetaldehyde was examined in vivo by monitoring changes in salivary half-life of antipyrine or aminopyrine in adult male Sprague-Dawley rats. Ethanol (1-6 g/kg, po) or acetaldehyde (4-8 mmol/kg, ip) was administered 20 minutes prior to antipyrine (100 mg/kg, ip) or...
Resource Type:: Dissertation
Full Text:: -dependent (0-96%) manner. The effect of acetaldehyde was minimal (23%) and not dose-dependent. Neither

Acetylcholine synthesis, storage, degredation and nicotinic receptores in a rat model for space-induced muscle atrophy

Creator:: Royland, Joyce E.
Abstract:: Space flight results in loss of mass and function in skeletal muscle. Data from manned flights and animal biosatellites give evidence of possible changes in neuromuscular interactions. Components at the neuromuscular junction are a potential site of action for this space-induced muscle atrophy. We examined the nicotinic acetylcholine receptor population...
Resource Type:: Dissertation
Full Text:: all 4 muscles, with the time to effect varying depending on the muscle and the enzyme. No

Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts

Creator:: Kwon, Sun Hyung
Abstract:: The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
Resource Type:: Masters Thesis
Full Text:: ). The physiological effects of many extracellular stimuli, such as hormones, growth factors and

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Creator:: Buckholz, Cheryl J.
Abstract:: Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been a mechanistic determination of the hepatotoxicity associated...
Resource Type:: Dissertation
Full Text:: -241) and colon (CRL 1790) cell lines. The presence of FMO could result in a first-pass effect

Correlation of fecal ergovaline, lolitrem B, and their metabolites in steers fed endophyte infected perennial ryegrass straw

Creator:: Murty, Lia D.
Abstract:: Perennial ryegrass (PRG, Lolium perenne) is a hardy cool-season grass that is infected with the endophytic fungus Neotyphodium lolii, which enables the plant to be insect repellant and drought resistant, lowering the use of insecticides and fertilizers. However, this fungus produces the compound lolitrem B (LB, m/z 686.4) which causes...
Resource Type:: Masters Thesis
Full Text:: neurological effects. Other physiological effects such as increased blood pressure, heart rate and

The study of pharmacokinetics in a clinical environment

Creator:: Tse, Sunny
Abstract:: This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Resource Type:: Dissertation
Full Text:: APREPITANT CONCENTRATIONS ................................................... 86 3.2 OBSERVED EFFECT OF

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

Creator:: DuBois, Barent Nathan
Abstract:: Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. I hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Pregnant...
Resource Type:: Dissertation
Full Text:: disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth

ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

Purine nucleotide-induced seizures in rat prepiriform cortex

Adenosine receptor modulation of seizure susceptibility in rats

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Modulation of sensory afferent processing by endogenous spinal adenosine

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Elimination of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid when normalized to urinary creatinine

Site-specific labeling of the cardiac glycoside receptor Na⁺,K⁺-ATPase : synthesis of a C-17 side group photoaffinity label ; Relationship of cardioactive steroid structure and conformation to biological activity

Modification of the acute effects of ethanol or acetaldehyde on drug metabolism by ascorbic acid, thiamine, or cysteine in vivo

Acetylcholine synthesis, storage, degredation and nicotinic receptores in a rat model for space-induced muscle atrophy

Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Correlation of fecal ergovaline, lolitrem B, and their metabolites in steers fed endophyte infected perennial ryegrass straw

The study of pharmacokinetics in a clinical environment

Programming of Furosemide Pharmacokinetics by Intrauterine Growth Restriction and High Fat Diet in the Adult Rat

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