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  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
    Resource Type:
    Dissertation
    Full Text:
    work. I also thank my thesis committee members Dr. Mark Zabriskie, Dr. Kerry McPhail, Dr. Fred

  • Studies toward the synthesis of coibamide A and analogues

    Creator:
    Li, Dong
    Abstract:
    Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
    Resource Type:
    Dissertation
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    to thank Dr. Kerry L. McPhail for this exciting compound coibamide A and all her lab members for

  • Ascorbylation- the biological relevance of covalently bound ascorbic acid

    Creator:
    Kesinger, Nicholas G.
    Abstract:
    Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'. The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
    Resource Type:
    Dissertation

  • Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

    Creator:
    Serrill, Jeffrey D.
    Abstract:
    Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
    Resource Type:
    Dissertation
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    academics. I would like to thank Dr. Kerry McPhail for acting as an active, supportive collaborator, and

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and

  • Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

    Creator:
    Hau, Andrew M.
    Abstract:
    Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
    Resource Type:
    Dissertation
    Full Text:
    . Proteau and Kerry L. McPhail. TABLE OF CONTENTS Page CHAPTER ONE: GENERAL INTRODUCTION