Index Catalog // ScholarsArchive@OSU

Characterization of rodent selenoprotein W promoter

Creator:: Amantana, Adams
Abstract:: Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
Resource Type:: Dissertation
Full Text:: Selenoprotein W Promoter Abstract approved: Philip D. Whanger Rat selenoprotein W (SeW) promoter activity was

Biochemical and molecular characteristics of selenoprotein W

Creator:: Gu, Qiu-Ping
Resource Type:: Dissertation
Full Text:: Biochemical and molecular characteristics of selenoprotein W

Selenoprotein W : distribution and function in rat tissue and cultured cells

Creator:: Sun, Yu, 1963-
Abstract:: The objective of this study was to further determine the distribution of selenoprotein W (SeW) in tissues from rats and sheep fed different selenium levels and to search for the possible functions of this protein. In the rat study a total of 28 rat tissues were examined and SeW was...
Resource Type:: Dissertation
Full Text:: Selenoprotein W: Distribution and Function in Rat Tissues and

Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Creator:: Ryu, Byung-Woo
Resource Type:: Dissertation
Full Text:: -p-dioxin Exposure in C57BU6J Male Ahd/A-Mice. Abstract approved: ( H W. Schaup The halogenated

Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice

Creator:: Sparrow, Barney R.
Abstract:: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on hepatic pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah[superscipt b/b male mice. A dose-dependent reduction of PC levels and activity occurred in animals given a single intraperitoneal dose of TCDD in a corn oil carrier. The dose ranged from 1 to...
Resource Type:: Dissertation
Full Text:: proud to of had Dr. Henry W. Schaup as my major professor. His insight, energy and enthusiasm for

An assessment of the cardiac toxicity of compounds that cause methemoglobinemia using a non-vascularized fish heart model

Creator:: Nichols, John W.
Abstract:: Non-vascularized hearts of buffalo sculpin (Enophrys bison) were used to investigate the cardiac toxicity of compounds that cause methemoglobinemia. The affinity of sculpin cardiac myoglobin for oxygen (P50 = 1.10 torr at 20 C°, pH 7.8) was lower than that of mammals studied (P50 = .44 and .76 torr for...
Resource Type:: Dissertation
Full Text:: TOXICITY OF COMPOUNDS THAT CAUSE METHEMOGLOBINEMIA USING A NON-VASCULARIZED FISH HEART MODEL by John W

Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons

Creator:: Berman, Frederick W.
Abstract:: A model of acute glutamate- and domoate-induced toxicity was developed and characterized in cultured rat cerebellar granule cells (CGCs) using experimental conditions which preserve the voltage-dependency of NMDA receptor function. Glutamate, which is normally non-toxic to CGCs in physiologic media (pH 7.4), was shown to induce a cytotoxic response after...
Resource Type:: Dissertation
Full Text:: domoate toxicity in cultured rat cerebellar granule neurons AN ABSTRACT ON THE THESIS OF Frederick W

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: acknowledge the advice and participation of my committee members; Dr. Daniel P. Selivonchick, Dr. Henry W

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Creator:: Chung, Woon-Gye
Resource Type:: Dissertation
Full Text:: . Tinsley and David W. Williams for their help as my committee. I would like to thank Ms. Elisabeth

Exposure and health risk assessment for farmers occupationally exposed to chlorpyrifos in Sri Lanka and drinking water and house dust analysis for chlorpyrifos

Creator:: Aponso, G. Lalith M.
Abstract:: This study was designed to assess chiorpyrifos exposure of a group of farmers by determining internal dose associated with a given application of this insecticide. This involved the monitoring of urinary levels of 3,5,6 trichloro-2-pyridinol (TCP), the major metabolite of chlorpyrifos. Incidental exposure was evaluated by determining the levels of...
Resource Type:: Dissertation

ScholarsArchive@OSU

Characterization of rodent selenoprotein W promoter

Biochemical and molecular characteristics of selenoprotein W

Selenoprotein W : distribution and function in rat tissue and cultured cells

Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice

An assessment of the cardiac toxicity of compounds that cause methemoglobinemia using a non-vascularized fish heart model

Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Exposure and health risk assessment for farmers occupationally exposed to chlorpyrifos in Sri Lanka and drinking water and house dust analysis for chlorpyrifos

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