Index Catalog // ScholarsArchive@OSU

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF David J. Castro for the degree of Doctor of Philosophy in Toxicology presented on February

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: activation AN ABSTRACT OF THE DISSERTATION OF David M. Shepherd for the degree of Doctor of Philosophy

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: members of my graduate comittee Dr. Christophen Bayne, Dr. David Hinton, and Dr. David Williams, for

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: express my appreciation to my committee members: Dr. David Williams, Dr. Ian Tinsley and Dr. Valerian

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: scientist: Nancy Kerkvliet, Michael Freitag, Siva Kolluri, David Hendrix, Kim Anderson, and Anna Harding

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: . David Barnes, Dr. Christopher Bayne, Dr. Jerry Heidel, and Dr. Henry Schaup, thank you for your

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: thank to my committee members: Dr. Christopher Bayne, Dr. Jerry Heidel, Dr David Williams, Dr. Olaf

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Creator:: Tidwell, Lane G.
Abstract:: Passive sampling devices (PSDs) were used to measure air vapor and water dissolved phase concentrations of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) at two different environmentally contaminated sites. Environmental contaminates like PAHs and OPAHs are present in both the atmospheric and aqueous environmental compartments. It is known that...
Resource Type:: Dissertation
Full Text:: , patience and unwavering support. My graduate committee members Drs. David Williams, Dave Stone, Staci

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Creator:: Park, Yeong-Chul
Resource Type:: Dissertation
Full Text:: extended to my committee members Dr. David W. Barnes, Dr. Annette M. Rossignol, Dr. Ian J. Tinsley, Dr

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Creator:: Chung, Woon-Gye
Resource Type:: Dissertation
Full Text:: . Tinsley and David W. Williams for their help as my committee. I would like to thank Ms. Elisabeth

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: laboratory, especially Lisa Truong and Jane LaDu for training me. A special thanks to David Bradford

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Creator:: Lee, JungA
Abstract:: Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Resource Type:: Masters Thesis
Full Text:: appreciation to Professors Lawrence R. Curtis and David B. Williams for their expertise and encouragement in

Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Creator:: Ryu, Byung-Woo
Resource Type:: Dissertation
Full Text:: , hairless mice, and on rabbit ears (McConnell and Moore 1979), Although there is variation in the degree

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: cooperation of Dr. David E. Williams, Dr. Donald R. Buhler, Dr. Carl B. Schreck, Dr. Steven L. Davis and the

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on Staphylococcal Enterotoxin B(SEB)-induced alterations in T-cell activation and cytokine production

Creator:: Huang, Wentian
Resource Type:: Dissertation
Full Text:: Lawrence, Dr. Jefferson Fowles, Dr. Gregory DeKrey, Linda Steppan, Julie Oughton, Rodney Prell, David

The determination of selected polychlorinated dibenzo-p-dioxins and dibenzofurans in environmental samples from sites associated with the use of chlorophenolic wood preservatives

Creator:: Hackett, Murray
Abstract:: Polychlorinated dibenzo-p-dioxins (PCDD's) and dibenzofurans (PCDF's) are environmental pollutants associated with the production and use of a number of industrial chemicals. In addition, PCDD's and PCDF's are produced during low temperature combustion of wastes containing polyvinylchloride (PVC), chlorophenols, and a number of other chemical precursors. A significant source of environmental...
Resource Type:: Masters Thesis

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: David M. Shepherd Technical support; critical review of manuscript Elena S. Spanjaard Technical support

ScholarsArchive@OSU

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on Staphylococcal Enterotoxin B(SEB)-induced alterations in T-cell activation and cytokine production

The determination of selected polychlorinated dibenzo-p-dioxins and dibenzofurans in environmental samples from sites associated with the use of chlorophenolic wood preservatives

The influence of aryl hydrocarbon receptor activation on T cell fate

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