Index Catalog // ScholarsArchive@OSU

Bioaccumulation profiles of chemical contaminants in fish from the lower Willamette River, Portland Harbor superfund site and human health risk assessment

Creator:: Sethajintanin, Doolalai
Abstract:: Concentrations of twenty-five PCBs, fifteen organochiorine pesticides and mercury were determined in recreational fish from the Willamette River, Oregon during the summer of 2000. Thirty-six fish samples of three fish species including black crappie, smalimouth bass and con-rn-ion carp were analyzed. The data reported here provides new information and recent...
Resource Type:: Masters Thesis
Full Text:: Health Risk Assessment. Abstract approved: Kim A. Anderson Concentrations of twenty-five PCBs, fifteen

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Creator:: Tidwell, Lane G.
Abstract:: Passive sampling devices (PSDs) were used to measure air vapor and water dissolved phase concentrations of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) at two different environmentally contaminated sites. Environmental contaminates like PAHs and OPAHs are present in both the atmospheric and aqueous environmental compartments. It is known that...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Kim A. Anderson Passive sampling devices (PSDs) were used to measure air vapor and water

Implications for Wildfire Health Recommendations and Remediation Strategies: Source, Fate and Risk of PAHs

Creator:: Ghetu, Christine, C.
Abstract:: (Polycyclic aromatic hydrocarbons) PAHs are widespread in the environment, and are derived from both natural and anthropogenic sources. The physicochemical properties of PAHs along with the wide range of PAH sources leads to their persistence in the environment. Since PAHs are ubiquitous, and have the potential to illicit adverse effects,...
Resource Type:: Dissertation
Full Text:: exposure. Additionally, a wider range of PAHs needs to be studied, including larger ring size PAHs and

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Kerri A. Stanley for the degree of Doctor of Philosophy

A Multi-Tiered Approach Using Daphnia magna to Assess Chlorpyrifos Risk to Aquatic Receptors

Creator:: Maggio, Stephanie A.
Abstract:: Chlorpyrifos (CPF) is a widely used broad-spectrum organophosphate insecticide. Following exposures, CPF and its more toxic oxon metabolite (CPFO) elicit neurotoxic effects by inhibiting the activity of the acetylcholinesterase enzyme (AChE), resulting in altered fitness and death at high doses. Following exposure, organisms bioactivate CPF to CPFO through the Cytochrome...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Stephanie A. Maggio for the degree of Doctor of Philosophy in Toxicology presented on

Investigations into the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression: effects on dendritic cell phenotype and function

Creator:: Vorderstrasse, Beth A.
Abstract:: T cell-dependent immune responses are highly sensitive to suppression by exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), yet direct effects of TCDD on T cells have been difficult to demonstrate. Because the activation of naive T cells is initiated by dendritic cells (DC), the studies presented in this dissertation were...
Resource Type:: Dissertation
Full Text:: Abstract of the Dissertation of Beth A. Vorderstrasse for the degree of Doctor of Philosophy in Toxicology

Investigation of the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity in C57B1/6 mice : effects on T cell activation

Creator:: Prell, Rodney A.
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Rodney A. Prell for the degree of

Selenium and trace metal accumulation in detrital-benthic food webs of lotic and lentic wetlands, Utah, USA

Creator:: Hillwalker, Wendy E.
Abstract:: Concentrations of selenium (Se), manganese (Mn), zinc (Zn), cadmium (Cd), lead (Pb) and arsenic (As) were measured in the water column, sediment and biota, in conjunction with selected physicochemical data, from representative wetland types at a mining site within Salt Lake County, Utah, USA. The selected field sites included Oolitic...
Resource Type:: Dissertation
Full Text:: ecotoxicology; concepts and applications Newman MC, Mcintosh A, eds. Chelsea, MI: Lewis Publishers, Inc. 243

A novel apparatus for estimating pesticide volatility from spray droplets

Creator:: Poel, Jeff D.
Resource Type:: Masters Thesis
Full Text:: Master of Science in Toxicology presented on December 4, 1996. Title: A Novel Apparatus for Estimating

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Creator:: Wilson, Lindsay B.
Abstract:: The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Resource Type:: Dissertation
Full Text:: people to whom I owe a huge thank you. To my family, Mom, Derek, Chelsea, Ryan, River, I hope to

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: of Doctor of Philosophy in Toxicology presented on April 14. 1995. Title: Vitellogenesis: A

Development and evaluation of the mallard duck as a model to investigate the immunotoxicity of environmental chemicals

Creator:: Fowles, Jefferson R.
Resource Type:: Dissertation
Full Text:: Evaluation of the Mallard Duck as a Model to Investigate the Immunotoxicity of Environmental Chemicals

The determination of selected polychlorinated dibenzo-p-dioxins and dibenzofurans in environmental samples from sites associated with the use of chlorophenolic wood preservatives

Creator:: Hackett, Murray
Abstract:: Polychlorinated dibenzo-p-dioxins (PCDD's) and dibenzofurans (PCDF's) are environmental pollutants associated with the production and use of a number of industrial chemicals. In addition, PCDD's and PCDF's are produced during low temperature combustion of wastes containing polyvinylchloride (PVC), chlorophenols, and a number of other chemical precursors. A significant source of environmental...
Resource Type:: Masters Thesis
Full Text:: with the production and use of a number of industrial chemicals. In addition, PCDD's and PCDF's are

Characterization of pyruvate carboxylase responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in C57BL/6J male Ah[superscript d/d] mice

Creator:: Ryu, Byung-Woo
Resource Type:: Dissertation
Full Text:: , Lewis Publishers, Chelsea. MI. 15 Martin, G., Vincent, N., Combet, C., and Baverel, G. (1993). A

Chemical and environmental factors affecting pesticide volatilization from turfgrass

Creator:: Conway, Michael S.
Abstract:: Volatile loss rates of pesticides from turfgrass were measured using the Backward-Time Lagrangian Stochastic Dispersion model (Flesch et al., 1995). Solar radiation, ambient temperature, surface temperature, relative humidity, wind direction, and wind speed were monitored continuously. Growth regulator was applied to the turf plot several days before pesticide application to...
Resource Type:: Masters Thesis
Full Text:: to the turf plot several days before pesticide appliOation to maintain a constant grass height and

Absorption and metabolism of selenite by perfused small intestine, and hepatocytes from rats

Creator:: Park, Yeong-Chul
Resource Type:: Dissertation
Full Text:: toxic effects of selenite. Both systems exhibited a high tolerance to selenite toxicity: Effective

The effect of vitamin B₁₂ on selenium and arsenic metabolism

Creator:: Chen, Chiareiy Liu
Resource Type:: Dissertation
Full Text:: selenium compounds (McConnell 1952). Trimethylselenonium (TMSe) was identified as a major metabolite in

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: DNA damage. Rainbow trout were fed a diet that contained a mixture of nine high molecular weight

Chlordecone impaired biliary excretion : in vivo and in vitro correlates

Creator:: Rochelle, Lori G.
Resource Type:: Dissertation
Full Text:: In Vitro Correlates Abstract approved: Redacted for Privacy Lawrence R. Curtis The liver is a

Susceptibility of riparian soil invertebrates to the herbicide triclopyr

Creator:: Moran, Patrick (Patrick William)
Abstract:: Riparian zones of Pacific Northwest forests have high species diversity and abundance and act as an important interface between the aquatic and terrestrial ecosystems. In addition, riparian zones comprise a significant portion of the total buffer zone established during commercial forest production to protect aquatic ecosystems from adjacent management activities....
Resource Type:: Masters Thesis
Full Text:: important interface between the aquatic and terrestrial ecosystems. In addition, riparian zones comprise a

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: (McConnell et al., 1978). TCDD causes a loss of lymphoid tissue (lymphoid involution) in the thymus, spleen

Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice

Creator:: Sparrow, Barney R.
Abstract:: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on hepatic pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah[superscipt b/b male mice. A dose-dependent reduction of PC levels and activity occurred in animals given a single intraperitoneal dose of TCDD in a corn oil carrier. The dose ranged from 1 to...
Resource Type:: Dissertation
Full Text:: pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah" male mice. A dose-dependent

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Creator:: Lee, JungA
Abstract:: Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Resource Type:: Masters Thesis
Full Text:: CHOLESTEROL DISPOSITION BY CHLORDECONE IS NOT EXPLAINED BY INDUCTION OF Cyp7a OR Cyp4al by JungA Lee A

The progression of aflatoxin B₁ (AFB₁) hepatocarcinogenesis in rainbow trout (Oncorhynchus mykiss) : I. AFB₁ metabolism and cytotoxicity affecting hepatocarcinogenesis II. Ultrastructure of hepatocellular neoplasms

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: -binding and histopathological analysis, respectively. Results indicated a linear dose-response in both

Assessment of exposure and response to atmospherically-derived contaminants in U.S. Arctic freshwater fish

Creator:: Allen-Gil, Susan M.
Abstract:: The Arctic has long been considered to be a pristine environment, far from population centers and pollution sources. The detection of synthetic organochlorine compounds in various elements of the Arctic food web has confirmed the global dispersion of pollutants, particularly of persistent compounds such as organochlorines and heavy metals. Levels...
Resource Type:: Dissertation
Full Text:: approved: Lawrence R. Curtis The Arctic has long been considered to be a pristine environment, far

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p -dioxin (TCDD

Photo-enhanced Toxicity of Oil Constituents and Corexit 9500 to Gulf of Mexico Marine Organisms

Creator:: Finch, Bryson E.
Abstract:: Significant inputs of hydrocarbons are continually released into the environment from anthropogenic and natural sources. Some of the most toxic hydrocarbon compounds are polycyclic aromatic hydrocarbons. Polycyclic aromatic hydrocarbons are known for their ability to absorb ultraviolet light and enhance toxicity. Generally, PAHs exert their toxicity via narcosis but UV-absorbing...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________________________ William A. Stubblefield Significant inputs of hydrocarbons are continually released into

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: toxicity information available. Assessing such a large number of chemicals using traditional methods

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on Staphylococcal Enterotoxin B(SEB)-induced alterations in T-cell activation and cytokine production

Creator:: Huang, Wentian
Resource Type:: Dissertation
Full Text:: (TCDD) is an environmental contaminant that is a potent immunotoxicant. To date, the cellular

Total exposure profiles of azinphosmethyl and azinphosmethyl-oxon to orchard workers in the Pacific Northwest

Creator:: Moate, Thomas F.
Resource Type:: Masters Thesis
Full Text:: residues of azinphosmethyl (azm) and azinphosmethyl- oxon (azm-o) in a Pacific Northwest apple orchard

Sublethal effects of estuarine carbaryl applications on juvenile English sole (Pleuronectes vetulus)

Creator:: Pozarycki, Scott V.
Abstract:: The pesticide carbaryl is applied annually to tidelands in Willapa Bay and Grays Harbor, WA to control populations of burrowing shrimp which modify sediments making the habitat unsuitable for oyster culture. Fish trapped on sprayed mudflats are often killed, but little is known about effects on fish present in subtidal...
Resource Type:: Dissertation
Full Text:: effects on fish present in subtidal channels or migrating over treated mudflats with a flood tide. The

Effects of esfenvalerate on native macroinvertebrates representative of Pacific Northwest streams

Creator:: Johnson, Katherine R.
Abstract:: Aquatic insects are essential components of healthy stream ecosystems, contributing to nutrient cycling, trophic dynamics and other ecological functions. Aquatic insect species, particularly those in the orders Ephemeroptera, Plecoptera and Trichoptera (EPT taxa) are however, extremely sensitive to insecticide contamination. Given that urban and agricultural use of synthetic pyrethroid insecticides...
Resource Type:: Dissertation
Full Text:: contamination by these compounds may pose a risk to aquatic insect species. The overarching hypothesis of this

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: activated antigen-specific T cells. A graft-versus-host (GVH) model, in which T cells from C57B1/6 (B6

Comparative Aquatic Toxicology of Pesticides and Plastics Using the Model Estuarine Fish, Inland Silverside

Creator:: Hutton, Sara J.
Abstract:: Based on current trends both pesticide and plastic production are expected to continue to rise in the coming decade. A growing global population coupled with the effects of climate change are the main drivers of increased pesticide use. Throughout this dissertation pesticides refer to herbicides, fungicides, and insecticides. Plastic production...
Resource Type:: Dissertation
Full Text:: expected to continue to rise in the coming decade. A growing global population coupled with the effects

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: + cells represented a systemic inflammatory response and were an immunomodulatory population that

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Creator:: Chung, Woon-Gye
Resource Type:: Dissertation
Full Text:: both male and female F344 rats produced higher SN N- oxidation (a detoxification pathway) by 88% and

Investigation of the mechanism of 3,3',4,4',5,5'-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine dysregulation

Creator:: DeKrey, Gregory K.
Resource Type:: Dissertation
Full Text:: dibenzo-p-dioxin (TCDD)] causes a dose-dependent suppression of the alloantigen-stimulated splenic

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