Index Catalog // ScholarsArchive@OSU

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: physiological role for that enzyme has been defined, use of the term cholinesterase assumes AChE unless

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: supplementation are its estrogenic effect as seen in trout and its ability to induce cytochrome P45 Os involved

Biochemical and molecular characteristics of selenoprotein W

Creator:: Gu, Qiu-Ping
Resource Type:: Dissertation
Full Text:: effect of substantially high selenium levels on human health was found in China, Enshi county of Hubei

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: promotes subcellular distribution of SR-BII to murine hepatic microsomes while having no effect on liver

Molecular and cellular mechanisms of aromatic hydrocarbon axonopathy

Creator:: Kim, Min-Sun
Abstract:: Hydrocarbon solvents are widely used in the production of paints, adhesives, dyes, polymers, plastics, textiles, printing inks, agricultural products and pharmaceuticals. While the neuropathic potential of aliphatic solvents was shown in the 1970s, little is known about the neuropathic potential of aromatic solvents. The present study examines such solvents, 1,2-diethylbenzene...
Resource Type:: Dissertation
Full Text:: 3.1 In-vitro effect of diacetylbenzene isomers on test proteins bovine serum albumin and ribonuclease

Mechanisms of inhibition of chemical carcinogenesis by indole-3- carbinol in the rat

Creator:: Stresser, David M.
Resource Type:: Dissertation
Full Text:: Effect of dietary I3C and BNF, alone or in combination, on the in vitro hepatic microsome-mediated

Selenoprotein W : distribution and function in rat tissue and cultured cells

Creator:: Sun, Yu, 1963-
Abstract:: The objective of this study was to further determine the distribution of selenoprotein W (SeW) in tissues from rats and sheep fed different selenium levels and to search for the possible functions of this protein. In the rat study a total of 28 rat tissues were examined and SeW was...
Resource Type:: Dissertation
Full Text:: SELENOPROTEINS 7 MAMMALIAN SELENOPROTEINS 14 CHAPTER 2 EFFECT OF DIETARY SELENIUM ON SELENOPROTEIN W AND

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:: Ruby, Carl E.
Abstract:: In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Resource Type:: Dissertation
Full Text:: .................................................................................. Tab'e of Contents (Continued) Page Chapter 4: Effect of 2,3,7,8 Tetrachlorodibenzo-p-Dioxin on Nitric

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: DIM exposures in rodent models to further elucidate the effect these compounds might have on health

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Creator:: Wang, Qi
Abstract:: Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
Resource Type:: Masters Thesis
Full Text:: ........................................................ . Effect of Mlhl status on cell survival to ionizing radiation ........................ . Mutagenic

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: ) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution

Pyrethroid insecticide interaction with the GABAA receptor and the peripheral-type benzodiazepine receptor of rainbow trout brain

Creator:: Eshleman, Amy J.
Abstract:: The peripheral-type benzodiazepine receptor (PTBR) of trout brain was pharmacologically characterized and pyrethroid interaction with this site investigated. High-affinity binding sites for [³H]PK 11195 were detected in brain membranes of rainbow trout; these shared some of the characteristics of the PTBR of rodent brain (i.e., high affinity for PK 11195...
Resource Type:: Dissertation
Full Text:: effect a GABA- dependent inhibition of [35S]TBPS binding. Ro5-4864, which showed micromolar affinity

Effect of xenoestrogen exposure on the expression of cytochrome P450 isoforms in rainbow trout liver

Creator:: Intharapanith, Sirinmas
Resource Type:: Masters Thesis
Full Text:: degree of Master of Science in Toxicology presented on December 12, 1995. Title: Effect of Xenoestrogen

Alterations in mink reproductive physiology following exposure to coplanar and noncoplanar polychlorinated biphenyls (PCBs)

Creator:: Patnode, Kathleen A., 1959-
Abstract:: Female mink (Mustela vison) are highly sensitive to polychlorinated biphenyl (PCB)-induced reproductive impairment. The goal of this research was to develop a better understanding of the mechanism of PCB-induced effects on female mink, mink embryos, and surviving mink kits. Anestrous, juvenile female mink and pregnant, adult mink were exposed to...
Resource Type:: Dissertation
Full Text:: ) or alterations in receptor number and affinity in response to different physiological states

Total exposure profiles of azinphosmethyl and azinphosmethyl-oxon to orchard workers in the Pacific Northwest

Creator:: Moate, Thomas F.
Resource Type:: Masters Thesis
Full Text:: the understanding of pesticide residue attenuation and how environmental conditions effect

Bioaccumulation profiles of chemical contaminants in fish from the lower Willamette River, Portland Harbor superfund site and human health risk assessment

Creator:: Sethajintanin, Doolalai
Abstract:: Concentrations of twenty-five PCBs, fifteen organochiorine pesticides and mercury were determined in recreational fish from the Willamette River, Oregon during the summer of 2000. Thirty-six fish samples of three fish species including black crappie, smalimouth bass and con-rn-ion carp were analyzed. The data reported here provides new information and recent...
Resource Type:: Masters Thesis
Full Text:: biological and physiological data of fish sample 23 TEQ concentrations (pg/g, wet weight) in whole fish .33

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: . Effect of pH on cEH activity using TSO as substrate for cytosol ..................21 3.3. Effect of pH

Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:: Tilton, Susan C.
Abstract:: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...
Resource Type:: Dissertation
Full Text:: possible dual effect that enhances tumor incidence and decreases potential for metastasis. The estrogenic

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: comparison [32]. 8 The effect of the “responsive” Ahrb-1 allele (expressed as a hemizygote

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: a significant protective effect against oxidative stress in rainbow trout cell lines (Maracine and

Passive sampling devices as biological surrogates for evaluating seasonal bioavailability of hydrophobic organic contaminants in surface water

Creator:: Sethajintanin, Doolalai
Abstract:: The seasonal distribution of bioavailable organochiorine contaminants in surface water and the potential environmental factors influencing their bioavailability were evaluated. The study was carried at the lower Willamette River at Portland Harbor, Oregon where surface water runoff varied according to season. Bioavailable water concentrations of DDTs and PCBs were determined...
Resource Type:: Dissertation
Full Text:: geochemical or physiological conditions than in the laboratory. As a part of an assessment of the

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