Index Catalog // ScholarsArchive@OSU

Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Creator:: Erve, John C. L.
Abstract:: Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Resource Type:: Dissertation
Full Text:: . Abstract approved: Donald J. Reed, Ph.D. Glutathione, a ubiquitous intracellular tripeptide, protects

Sublethal effects of estuarine carbaryl applications on juvenile English sole (Pleuronectes vetulus)

Creator:: Pozarycki, Scott V.
Abstract:: The pesticide carbaryl is applied annually to tidelands in Willapa Bay and Grays Harbor, WA to control populations of burrowing shrimp which modify sediments making the habitat unsuitable for oyster culture. Fish trapped on sprayed mudflats are often killed, but little is known about effects on fish present in subtidal...
Resource Type:: Dissertation

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: and financial support. Thanks to Drs. Donald Reed, George Bailey, Mark Christensen and Wilbert Gamble

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

Creator:: Duringer, Jennifer Marie
Abstract:: The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated. Variability exists in the...
Resource Type:: Dissertation
Full Text:: . Morrie Craig was involved in the design, analysis and writing of each manuscript. Dr. Donald Buhler

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: Hypoplasia Observed in Otter Males. Abstract approved Donald R. Buhier A large number of river otter

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: : Donald R. Buhler A large number of river otter (Lontra canadensis) males were collected from areas of

Human Exposure to PAHs in Air, Water, and Crayfish

Creator:: Paulik, L. Blair
Abstract:: There are many links between exposure to environmental pollution and risks to human health. While advances in the fields of toxicology, exposure science, and environmental chemistry have shown light on many of these links, many more research challenges remain. One major challenge is how to accurately characterize the toxicity of...
Resource Type:: Dissertation
Full Text:: the manuscript. In Chapter 3, Carey Donald helped select sampling sites, design the sampling plan

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Creator:: Donald, Carey E.
Abstract:: Passive sampling devices have been used for decades to measure complex mixtures of bioavailable organic chemicals in a variety of environmental media. More recently passive sampler applications have expanded beyond monitoring chemical concentrations, and this dissertation continues to advance methods of passive sampling on many fronts. Despite their growing use,...
Resource Type:: Dissertation
Full Text:: E. Donald for the degree of Doctor of Philosophy in Toxicology presented on April 17, 2017 Title

Applications of Silicone Wristbands to Improve Personal Chemical Exposure Assessment

Creator:: Dixon, Holly M.
Abstract:: Silicone wristbands are easy-to-wear passive samplers that have been readily adapted into environmental health studies since first reported in 2014. Wristbands can be worn during normal daily activities and sequester a wide range of bioavailable organic chemicals. This dissertation includes a thorough review of silicone wristband technology, as well as...
Resource Type:: Dissertation
Full Text:: Donald, Dr. Alan Bergmann, Glenn Wilson, Pete Hoffman, Dr. Lane Tidwell, Dr. Jamie Minick, Carolyn

New Configurations of Silicone Passive Sampling Devices: Quantifying Feline and Firefighter Chemical Exposures

Creator:: Poutasse, Carolyn M.
Abstract:: Silicone wristbands are passive sampling devices (PSD) that sequester bioavailable organic chemicals in the environment. In environmental health studies, silicone wristbands are easy to wear and can provide personal exposure data about complex chemical mixtures. This dissertation includes an overview of PSD technology, a literature review of current wristband research...
Resource Type:: Dissertation
Full Text:: Hoffman, Gary Points III, Glenn Wilson, Dr. Kyle Messier, Dr. Carey Donald, Dr. Blair Paulik, Dr. Alan

ScholarsArchive@OSU

Alkylation of peptides and proteins by S-(2-chloroethyl)glutathione and characterization of adducts by mass spectrometry

Sublethal effects of estuarine carbaryl applications on juvenile English sole (Pleuronectes vetulus)

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Human Exposure to PAHs in Air, Water, and Crayfish

Advances in Passive Sampling : Measuring Chemical Transport and Human Exposures

Applications of Silicone Wristbands to Improve Personal Chemical Exposure Assessment

New Configurations of Silicone Passive Sampling Devices: Quantifying Feline and Firefighter Chemical Exposures

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