Index Catalog // ScholarsArchive@OSU

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Mitra Celestine Geier for the degree of Doctor of Philosophy

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: particular, due credit must go to Dr. Jill Franzosa, Dr. Mitra Geier, and Dr. Sumitra Sengupta for their

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Creator:: Holden, Laura, L.
Abstract:: Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
Resource Type:: Masters Thesis
Full Text:: prioritized for further studies (Geier et al., 2018a; Truong et 4 al., 2014). Furthermore, the

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:: Shankar, Prarthana
Abstract:: All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Resource Type:: Dissertation
Full Text:: Prarthana Shankar with editorial comments provided by Ryan S. McClure, Katrina M. Waters, Mitra C. Geier

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:: Chang, Yvonne
Abstract:: The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Resource Type:: Dissertation
Full Text:: increasing RPF with pathways for cell cycle S phase and cytoskeleton actin identified as the most

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: downstream defects unique to each surface functional group‟s property. In the next study, I tested the long

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: , Ivan Titaley, Lisandra Santiago Delgado, Justin Rewerts, Amber Kramer, Scott LaFontaine, Mitra Geier

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: encouragement as I was finding my place in the lab; Cory Gerlach, Amber Roegner, Mitra Geier, Anna Chlebowski

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Creator:: Rivera, Brianna N.
Abstract:: Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Resource Type:: Dissertation
Full Text:: ) ................................................................................................. 145 Table B.1. List of polycyclic aromatic hydrocarbon CAS#’s, detection limits, and

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

Creator:: Minick, David J.
Abstract:: In the environment, it is the unbound fraction of chemical (Cfree) which is able to diffuse across environmental interfaces and biological membranes. It is therefore Cfree which drives many important biological-environmental processes including contaminant transport, bioaccumulation and toxicity. Passive sampling devices (PSDs) offer a simplified and more accurate approach for...
Resource Type:: Dissertation
Full Text:: Research Laboratory at Oregon State University including Dr. Robert Tanguay, Mitra Geier, and Lisa Truong

ScholarsArchive@OSU

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Developing rapid in vivo assays to investigate structure response relationships

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Advancement of Passive Sampling Applications for Assessing Contaminant Transport, Bioaccumulation, and Toxicity

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