Index Catalog // ScholarsArchive@OSU

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Claudia F. Bravo for the

Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Creator:: Troxel, Claudia McLaughlin
Resource Type:: Dissertation
Full Text:: of CYP1A induction on aflatoxin B₁ metabolism in zebrafish AN ABSTRACT OF THE THESIS OF Claudia

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: . Claudia Maier, who jumped in at the last minute as Graduate Council Representative and offered new

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

Creator:: Janney, Philip K.
Abstract:: Pacific Northwest and California freshwater resources are key elements in the life history and ecology of Pacific salmon and steelhead listed as threatened or endangered under the Endangered Species Act. Risk to listed Pacific salmonid species can be assessed by evaluating the spatial and temporal co-occurrence of salmonid species at...
Resource Type:: Dissertation
Full Text:: , and Dr. Claudia Maier for sticking with me over the years. I would like to thank all of the members

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: . William Stubblefield, Dr. Molly Kile, and Dr. Claudia Maier for their guidance and support. I would

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Creator:: Rivera, Brianna N.
Abstract:: Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Resource Type:: Dissertation
Full Text:: Susan C. Tilton & Kim A. Anderson Throughout their lifetime individuals are exposed to complex

Elucidating Structure-bioactivity Relationships and Modes of Action of Per- and Polyfluoroalkyl Substance Toxicity in Zebrafish

Creator:: Rericha, Yvonne
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are a broad class of anthropogenic chemicals characterized by highly stable carbon-fluorine (C-F) bonds. PFAS are widely used in industrial and consumer products for their surface-active and stain-resistant properties and are ubiquitously detected in environmental media, biota, and human biomatrices. Although some PFAS are known...
Resource Type:: Dissertation
Full Text:: anthropogenic chemicals characterized by highly stable carbon-fluorine (C-F) bonds. PFAS are widely used in

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:: Shankar, Prarthana
Abstract:: All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Resource Type:: Dissertation
Full Text:: Prarthana Shankar with editorial comments provided by Ryan S. McClure, Katrina M. Waters, Mitra C. Geier

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Creator:: Wilson, Lindsay B.
Abstract:: The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
Resource Type:: Dissertation
Full Text:: , Prarthana Shankar, Claudia Santillán, Ryan Lopez, Connor Leong, Laura Magaña, Mackenzie Morshead

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: to Dr. Claudia F. Bravo, Tyler S. Norby, and Linda G. Steppan assisted with data collection. I also

ScholarsArchive@OSU

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Continuous monitoring and modeling to assess pesticide exposure in critical habitat for Pacific salmonids

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Elucidating Structure-bioactivity Relationships and Modes of Action of Per- and Polyfluoroalkyl Substance Toxicity in Zebrafish

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Advanced Approaches in Hazard Assessment of Polycyclic Aromatic Hydrocarbons Using Zebrafish

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

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