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Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Creator:: Troxel, Claudia McLaughlin
Resource Type:: Dissertation
Full Text:: of CYP1A induction on aflatoxin B₁ metabolism in zebrafish AN ABSTRACT OF THE THESIS OF Claudia

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Claudia F. Bravo for the

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: , Dr. Michael Burgett, Dr. Lawrence Curtis and Dr. Barbara Taylor). Second is my labmates (Claudia

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: to Dr. Claudia F. Bravo, Tyler S. Norby, and Linda G. Steppan assisted with data collection. I also

Chlorophyllin chemoprevention against Dibenzo[a,l]pyrene-initiated multi-organ carcinogenesis in the rainbow trout model

Creator:: Pratt, Mary Margaret
Abstract:: Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental...
Resource Type:: Dissertation
Full Text:: . I am also grateful to my roommates and friends, Meltem, Annabelle, Sara, Afi, Claudia E., lyon

Biochemical and molecular characteristics of selenoprotein W

Creator:: Gu, Qiu-Ping
Resource Type:: Dissertation
Full Text:: . Claudia Maier for assistance in the peptide mapping, and all the members in Center of Gene Research and

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: Claudia Bravo, Francisco Madriñan, Stephanie Smith-Roe, the Rodgers and the Odegaards for their

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

Creator:: Rivera, Brianna N.
Abstract:: Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Resource Type:: Dissertation
Full Text:: inspiration that helped better me in so many ways. To my day ones, Stephanie Maggio and Claudia Santillan. I

ScholarsArchive@OSU

Aflatoxin B₁ metabolism, CYP1A induction, and the influence of CYP1A induction on aflatoxin B₁ metabolism in zebrafish

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Chlorophyllin chemoprevention against Dibenzo[a,l]pyrene-initiated multi-organ carcinogenesis in the rainbow trout model

Biochemical and molecular characteristics of selenoprotein W

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

Assessing Exposures and Simplifying Complex Mixtures of SVOCs for Hazard Characterization using Alternative Model Systems

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