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Filtering by: Subject Ketoconazole -- Mechanism of action Remove constraint Subject: Ketoconazole -- Mechanism of action Degree Field Toxicology Remove constraint Degree Field: Toxicology

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  • Characterization of rodent selenoprotein W promoter

    Creator:
    Amantana, Adams
    Abstract:
    Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
    Resource Type:
    Dissertation
    Full Text:
    MRE sequence are critical to the metal induction of SeW promoter. The mechanism underlying this

  • Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

    Creator:
    Tilton, Fred Anthony, 1973-
    Abstract:
    Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and effluent additives. DTCs and their related compounds have historical and current relevance in clinical and experimental medicine. DTC developmental toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a mechanism of action involving, "the inhibition of...
    Resource Type:
    Dissertation
    Full Text:
    mechanism of action involving, "the inhibition of metal-dependent and sulfhydryl enzyme systems in fungi