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Filtering by: Creator Mendez, Christopher Degree Field Toxicology

Developing rapid in vivo assays to investigate structure response relationships

Creator:

Truong, Lisa

Abstract:

Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...

Resource Type:

Dissertation
Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:

Chlebowski, Anna C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...

Resource Type:

Dissertation

Full Text:

Chibwe, Dr. Derik Haggard, Dr. Andrea Knecht, Dr. Christopher Walsh, Dr. Oleksi Motorykin, Dr. Narumol
Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:

Goodale, Britton C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...

Resource Type:

Dissertation

Full Text:

biological functions associated with RNA-seq transcripts. Christopher Sullivan processed RNA-seq data, and