Index Catalog // ScholarsArchive@OSU

Cytochrome P450 3A forms in rainbow trout (Oncorhynchus mykiss)

Creator:: Lee, Su-Jun
Resource Type:: Dissertation
Full Text:: . Marilyn Henderson, Mr. Robert Groove, and Ms. Meltem Yelmazar for their advice, help, and friendship in

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: Aromatic Hydrocarbon, Dibenzo[def,p] Chrysene; Carcinogenesis and Metabolism Abstract approved

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: Potential Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immune Suppression. Abstract

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Creator:: Usenko, Crystal Y.
Abstract:: Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
Resource Type:: Masters Thesis
Full Text:: approved: _____________________________________________________________ Robert L. Tanguay Due to

Consequences of miRNA misregulation on embryonic development and aging

Creator:: Franzosa, Jill A.
Abstract:: microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...
Resource Type:: Dissertation
Full Text:: approved:____________________________________________________________ Robert L. Tanguay microRNAs

The determination of selected polychlorinated dibenzo-p-dioxins and dibenzofurans in environmental samples from sites associated with the use of chlorophenolic wood preservatives

Creator:: Hackett, Murray
Abstract:: Polychlorinated dibenzo-p-dioxins (PCDD's) and dibenzofurans (PCDF's) are environmental pollutants associated with the production and use of a number of industrial chemicals. In addition, PCDD's and PCDF's are produced during low temperature combustion of wastes containing polyvinylchloride (PVC), chlorophenols, and a number of other chemical precursors. A significant source of environmental...
Resource Type:: Masters Thesis
Full Text:: The determination of selected polychlorinated dibenzo-p

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: :___________________________________________________________________________________ Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: \OtterThesis.wpd AN ABSTRACT OF THE DISSERTATION OF Robert Allan Grove for the degree of Doctor of Philosophy in

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Robert Allan Grove for the

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: Robert L. Tanguay Abstract Numerous human conditions would be improved if therapies to encourage

ScholarsArchive@OSU

Cytochrome P450 3A forms in rainbow trout (Oncorhynchus mykiss)

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Consequences of miRNA misregulation on embryonic development and aging

The determination of selected polychlorinated dibenzo-p-dioxins and dibenzofurans in environmental samples from sites associated with the use of chlorophenolic wood preservatives

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

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