Index Catalog // ScholarsArchive@OSU

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Creator:: Shepherd, David M.
Abstract:: The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
Resource Type:: Dissertation
Full Text:: The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell

Investigation of the mechanism of 3,3',4,4',5,5'-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine dysregulation

Creator:: DeKrey, Gregory K.
Resource Type:: Dissertation
Full Text:: '-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Creator:: Donohoe, Regina M.
Abstract:: Persistent organochlorines (OCs) bioaccumulate in aquatic biota and potentially impair reproduction via endocrine disruption. The present research evaluated estrogenic effects of the OCs, chlordecone (CD) and o,p'-DDT/DDE, and the antiestrogenicity of 3,4,5,3',4',5'-hexachlorobiphenyl (345-HCB) in juvenile rainbow trout, utilizing vitellogenesis as a biomarker. Vitellogenesis, estrogen regulated hepatic production of the yolk...
Resource Type:: Dissertation
Full Text:: 1011- 1062. Raven Press, New York. 11 Colborn, T., and Clement, C. (1992). Chemically-Induced

Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons

Creator:: Berman, Frederick W.
Abstract:: A model of acute glutamate- and domoate-induced toxicity was developed and characterized in cultured rat cerebellar granule cells (CGCs) using experimental conditions which preserve the voltage-dependency of NMDA receptor function. Glutamate, which is normally non-toxic to CGCs in physiologic media (pH 7.4), was shown to induce a cytotoxic response after...
Resource Type:: Dissertation
Full Text:: Granule Neurons. Abstract approved: Thomas F. Murray A model of acute glutamate- and domoate-induced

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:: Chang, Yvonne
Abstract:: The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Susan C. Tilton The

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:: Shankar, Prarthana
Abstract:: All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Resource Type:: Dissertation
Full Text:: Du. Britton C. Goodale originally identified wfikkn1. Gloria R. Garcia, Jane K. La Du, and

Species difference in bioactivation and detoxification of pyrrolizidine (senecionine) alkaloids

Creator:: Huan, Jianya
Resource Type:: Dissertation
Full Text:: Bioactivation and Detoxification of Pyrrolizidine (Senecionine) Alkaloids. Abstract approved: Peter R

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Creator:: Chung, Woon-Gye
Resource Type:: Dissertation
Full Text:: financial support as my major professor. I also thank Drs. Peter R. Cheeke, Martin S. Fitzpatrick, Ian J

Xenobiotic biotransformation in aquatic organisms

Creator:: Schlenk, Daniel K.
Abstract:: Aquatic animals are exposed to a variety of natural and anthropogenic xenobiotics. Biotransformation of xenobiotics was examined in three aquatic animals: a primitive mollusc (chiton); a shellfish which is an important human food source (oyster); and, a lower vertebrate model for toxicological studies (rainbow trout). Since digestive glands of Cryntochiton...
Resource Type:: Dissertation
Full Text:: Abstract approved: Donald R. Buhler Aquatic animals are exposed to a variety of natural and

In vitro metabolism of pyridine and chlorpyrifos by rainbow trout liver microsomes

Creator:: Wong, Sue Sun
Resource Type:: Masters Thesis
Full Text:: Chlorpyrifos by Rainbow Trout Liver Microsomes .Redacted for Privacy Abstract approved: Donald R. Buhler

ScholarsArchive@OSU

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

Investigation of the mechanism of 3,3',4,4',5,5'-hexachlorobiphenyl-induced suppression of cytotoxic T lymphocyte activity in C57B1/6 mice : endocrine and cytokine dysregulation

Vitellogenesis : a biomarker for estrogenic and antiestrogenic effects of organochlorines in rainbow trout

Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Species difference in bioactivation and detoxification of pyrrolizidine (senecionine) alkaloids

Comparative metabolism of the pyrrolizidine alkaloid senecionine in rat and guinea pig

Xenobiotic biotransformation in aquatic organisms

In vitro metabolism of pyridine and chlorpyrifos by rainbow trout liver microsomes

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