Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
A synthetic approach toward the two major fragments of cathedulin K-19,
euonyminol (4) and dimethyl cathate (69), was investigated. Synthesis of
dimethyl cathate was accomplished in 3 steps starting from 73. Efforts directed
towards the synthesis of euonyminol, a highly oxygenated dihydroagarofuran
sesquiterpene, was advanced to a stage in which...
Recent state and national standards have increased the interest in engineering at the K-12 level. Science standards, in particular, have begun to make the case for including engineering throughout the K-12 scope of study. Despite the increased attention to engineering, the characteristics and uniqueness of the field of engineering are...
The differential cross section for the reaction k⁻+p[forward arrow] k⁰+[uppercase xi]⁰ was measured in a spark chamber experiment for an incident k⁻ momentum of 1.8 GeV/c. The target was liquid hydrogen confronted
by an anti-coincidence counter to insure neutral particle production.
A 60 element hodoscope signalled the presence of four...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Two light sensitive mutants of the green alga Scenedesmus obliquus strain D₃ have been characterized. The photodynamic nature of their sensitivity has been established, the subchloroplast site of photodamage has been investigated, and their noncarotenogenic character has been verified. The two mutants possess several similarities, although mutant L. S. -41...