Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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the Berkeley Center for Structural Biology supported in part by the National Institutes of
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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is weaker than that of the Cys93 Sγ, consistent with the iron having 5
decreased occupancy. We
There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
A mixed initial and boundary value problem is considered for
a partial differential equation of the form Muₜ(x, t)+Lu(x, t)=0,
where M and L are elliptic differential operators of orders 2 m
and 2l, respectively, with m ≤ l. The existence and uniqueness
of a strong solution of this equation...
The history of entomopathogenic nematology is briefly reviewed. Topic selections include early descriptions of members
of Steinernema and Heterorhabditis, how only morphology was originally used to distinguish between the species; descriptions of the
symbiotic bacteria and elucidating their role in the nematode- insect complex, including antibiotic properties, phase variants, and...
Quantitative literacy is essential to biological literacy (and is one of the core concepts in Vision and Change in Undergraduate Biology Education: A Call to Action; AAAS 2009). Building quantitative literacy is a challenging endeavor for biology instructors. Integrating mathematical skills into biological investigations can help build quantitative literacy. In...
In 1959 the British Ornithological journal, The Ibis, published a centenary commemorative volume on the history of ornithology in Britain. Over the previous few decades, the contributors to this volume had helped focus the attention of ornithologists on the methods, priorities, and problems of modem biology, specifically the theory ofevolution...
Importance sampling algorithms are discussed in detail, with an emphasis on implicit sampling, and applied to data assimilation via particle filters. Implicit sampling makes it possible to use the data to find high-probability samples at relatively low cost, making the assimilation more efficient. A new analysis of the feasibility of...
In this paper we extend the results of the research started by the first author in which Karlin-McGregor diagonalization of certain reversible Markov chains over countably infinite general state spaces by orthogonal polynomials was used to estimate the rate of convergence to a stationary distribution. We use a method of...
The convolution inequality h ∗ h(ξ) ≤ B|ξ|θh(ξ) defined on Rⁿ
arises from a probabilistic representation of solutions of the n-dimensional
Navier-Stokes equations, n ≥ 2. Using a chaining argument, we establish
in all dimensions n ≥ 1 the nonexistence of strictly positive fully supported
solutions of this inequality for...
The efficacy of DNA extraction protocols can be highly dependent upon both the type of sample being investigated and the types of downstream
analyses performed. Considering that the use of new bacterial community analysis techniques (e.g., microbiomics, metagenomics) is becoming
more prevalent in the agricultural and environmental sciences and many...
This article concerns a systemic manifestation of small scale interfacial heterogeneities in large scale quantities of interest to a variety of diverse applications spanning the earth, biological and ecological sciences. Beginning with formulations in terms of partial differential equations governing the conservative, advective-dispersive transport of mass concentrations in divergence form,...
The purpose of this note is to provide a coupling of weak limits in distribution of sequence of (normalized) multiplicative cascade measures under strong disorder in terms of the extremes of an associated branching random walk, assuming i.i.d positive, non-lattice bond weights and a second moment condition. The solution is...
Advective skew dispersion is a natural Markov process defined ned
by a di ffusion with drift across an interface of jump discontinuity in
a piecewise constant diff usion coeffcient. In the absence of drift this
process may be represented as a function of -skew Brownian motion
for a uniquely determined...