Search Constraints

Start Over
Filtering by: Creator Chen, Peter Y. S. Remove constraint Creator: Chen, Peter Y. S. Degree Level Bachelor's Remove constraint Degree Level: Bachelor's Subject Microsatellites (Genetics) Remove constraint Subject: Microsatellites (Genetics)

Search Results

  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    with Xmn1 (Fermentas, Hanover, MD) in Y+/Tango buffer in a reaction volume of 200 μL according to

  • Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

    Creator:
    Mohamed, Aly
    Abstract:
    The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one...
    Resource Type:
    Honors College Thesis
    Full Text:
    Loci Fr eq ue nc y (% ) o f s hi fte d al le le s Figure 10: Frequency (%) of repeat