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Filtering by: Creator Thompson, Gene Thomas Degree Level Bachelor's Subject Nanoparticles

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish

Creator:

Pfarr, Shaylin H.

Abstract:

As nanoparticle (NP) research and development expands, the significance of NP biodistribution effects on toxicity increases. A reliable method for measuring NP biodistribution is critical. Hyperspectral Imaging (HSI) is capable of accurately quantitating NP biodistribution within embryonic zebrafish with incredibly high precision. Before HSI processing, the embryo must be sectioned...

Resource Type:

Honors College Thesis

Full Text:

/2017/02/Leica_CM1850-Cryostat- Manual.pdf 34 Lomer, M. C. E., Thompson, R. P. H., & Powell, J. J
Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Creator:

Engstrom, Arek

Abstract:

The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...

Resource Type:

Honors College Thesis

Full Text:

://doi.org/10.1016/j.jconrel.2016.06.017 Chapman, A., Arendorf, J., Castella, T., Thompson, P., Willis, P