The emergence of high explosives on the battlefield can be defined both literally and figuratively as a seismic event in the landscape of modern warfare. High explosives first came into common use in war in 1914. By the end of World War I just four years later, more than 2.5...
Sepsis is a blood infection that is caused by circulating bacteria cells and cell fragments, which contain immunogenic lipopolysaccharides (LPS) or endotoxin. The circulating endotoxin results in a severe dysregulation of the inflammatory response that ultimately leads to organ failure. One promising treatment method is removal of endotoxin by passing...
With the growing importance of sustainability, organizations in the non-profit
sector need a way to measure, track, improve, and report their sustainability. Through
research in current literature and a survey of practices within local non-profits, it is
shown these organizations need a simple, flexible process with stakeholder participation
to measure...
Sepsis, caused by bacterial release of endotoxin, is a serious blood infection that causes uncontrolled systemic immune response. In North America alone, sepsis kills between 220,000 and 380,000 people each year, more than prostate cancer, breast cancer, and HIV/AIDS combined. Sepsis treatment is complicated and often requires prolonged hospital stays,...
With growing awareness of the negative impacts of the built environment, solutions for dramatic environmental, economic, and social improvements are sparking in all sectors, especially within the construction industry. The work of this thesis aims to quantify and compare social, economic, and environmental impacts of a three-story mass timber structure...
Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...
The US industrial sector accounts for about one-third of the nation’s energy consumption and is predicted to grow twice as quickly as other sectors through 2050. International organizations such as the International Energy Agency project energy efficiency improvements will account for over 40% of greenhouse gas emissions reductions through 2040....
The potential of red blood cell (RBC) and platelet damage was studied for a novel microfluidic hemoperfusion device currently in development at Oregon State University for use in treating sepsis. COMSOL 4.4's computational fluid dynamics (CFD) module was used to examine shear rate profiles in laminar, Newtonian blood flow throughout...
Antimicrobial coatings used to reduce the risk of infection caused by tissue-contacting medical devices must address specific biocompatibility requirements including prevention of thrombosis and rise of bacterial resistance. An antimicrobial-loaded poly(ethylene-oxide) (PEO) coating has been tentatively shown to be non-fouling with sustained antimicrobial activity. However, the presence of the antimicrobial,...
SMEs with high-mix and low-volume (HMLV) operations face special challenges when implementing lean manufacturing practices due to scarcity of resources and ever changing market conditions. This is especially critical for manufacturers that need to deliver orders to a high variety of customers with varying time response requirements. The objective of...