Index Catalog // ScholarsArchive@OSU

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Presentation and Undergraduate Thesis

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Honors College Thesis
Full Text:: Andrew Buermeyer DNA mismatch repair (MMR) plays an important role in

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Creator:: Merschel, Andrew G.
Abstract:: Old-growth dry-mixed conifer forests are valued as habitats for late seral forest species, for the ecosystem services and landscape diversity they provide, and for their aesthetic appeal. The structure of these forests has been heavily altered by historic logging of overstory ponderosa pine and Douglas-fir. Additionally, changes in fire regime...
Resource Type:: Honors College Thesis
Full Text:: THE THESIS OF Andrew G. Merschel for the degree of Honors Baccalaureate of Science in Natural

Investigating the Role of the MutLα Endonuclease

Creator:: Mankaney, Gautam Naresh
Abstract:: Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
Resource Type:: Honors College Thesis
Full Text:: . Abstract Approved:________________________________________________________ Andrew Buermeyer Lynch

A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

Creator:: Nguyen, Andrew
Abstract:: Genomic integrity is crucial for the viability and function of a cell. One key pathway that acts to maintain genomic integrity is DNA mismatch repair (MMR). MMR acts to correct base pair mismatches hat have escaped proofreading during DNA replication. The process of MMR is dependent on the protein heterodimer...
Resource Type:: Honors College Thesis
Full Text:: Andrew Nguyen Honors Thesis AN ABSTRACT OF THE

Effects of estuary characteristics and tsunami waveforms on transported sand sheets

Creator:: Armstrong, Emma M.
Abstract:: The details of the 1700 Cascadia Subdction Zone earthquake and tsunami can be better constrained using data from tsunami sand sheets, provided knowledge of the waveform, estuary geometry and bed roughness controls on the deposition pattern of the sand sheet. In this study, we use the hydrodynamic and sediment transport...
Resource Type:: Undergraduate Thesis
Full Text:: , Science, 236(4804), 942-944. Carrier, G. F., T. T. Wu, and H. Yeh (2003), Tsunami run-up and draw-down

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:: O'Donnell, Edmond Francis
Abstract:: DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Resource Type:: Honors College Thesis
Full Text:: . Abstract Approved: Andrew Buermeyer DNA mismatch repair (MMR) is an evolutionary conserved process that

The toxicogenetic effects of a chitosan based hemostatic control patch in rat models

Creator:: Colburn, Andrew J.
Abstract:: Chitosan based hemorrhage control dressings provide effective external hemorrhage control while having few side effects. Known residual contaminants present in chitosan formulations include endotoxins and proteins known to stimulate gene expression in the liver. This study investigated gene expression in the liver using rat bio-compatibility models to gain knowledge regarding...
Resource Type:: Undergraduate Thesis and Presentation
Full Text:: Toxicogenetic Effects of a Chitosan Based Hemostatic Control Patch in Rat Models By Andrew J. Colburn

Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creator:: Wickramanayake, Anneka
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical compounds found in the environment, largely as a result of partial combustion of organic compounds. PAHs are present in the atmosphere in populated cities worldwide. Because of the health risks they create, PAHs are a global health concern. PAHs are introduced into the...
Resource Type:: Honors College Thesis
Full Text:: :____________________________________________________ Andrew Buermeyer Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic chemical

Creating Test Baking Methods Specifically for Whole-Wheat Sourdough Breads, In the Context of Local Grain Economies

Creator:: Jansen, Victoria E.
Abstract:: Recently local grains have become an area of economic growth. Local grain products, including whole-wheat and sourdough products, are increasingly in demand for their health benefits, unique flavor profiles, and association with local food movements. These local grain economies are beginning to boom, but they lack the technical aid that...
Resource Type:: Honors College Thesis
Full Text:: Andrew Ross Recently local grains have become an area of economic growth. Local grain products

ScholarsArchive@OSU

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Investigating the Role of the MutLα Endonuclease

A Novel Approach to the Biochemical Analysis of Variants in the Essential DNA Mismatch Repair Protein MLH1

Effects of estuary characteristics and tsunami waveforms on transported sand sheets

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

The toxicogenetic effects of a chitosan based hemostatic control patch in rat models

Mismatch Repair-Dependent Cellular Responses to Polycyclic Aromatic Hydrocarbons: An Investigation of Research Methods and Materials

Creating Test Baking Methods Specifically for Whole-Wheat Sourdough Breads, In the Context of Local Grain Economies

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