Index Catalog // ScholarsArchive@OSU

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Creator:: Huynh, Celine T.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are known to cause adverse health effects in the human lung. Here, we evaluated biomarkers relevant for PAH toxicity in a 3D human primary bronchial epithelial cell (HBEC) model collected from normal and asthmatic donors. We previously found that PAHs decrease cellular barrier function integrity, which...
Resource Type:: Honors College Thesis
Full Text:: Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells by Celine Huynh

Field-use electrochemical sensors for detection of carbamazepine in saliva and water

Creator:: Minzlaff, Jade
Abstract:: The anticonvulsant drug carbamazepine (CBZ) is a commonly prescribed drug that is used to treat patients with neurological disorders including epilepsy and bi-polar disorder. CBZ has a narrow range of efficacy: Below the therapeutic dose, seizures and other conditions are not controlled, and above the recommended window, patients experience side...
Resource Type:: Honors College Thesis
Full Text:: Fu The anticonvulsant drug carbamazepine (CBZ) is a commonly prescribed drug that is used

Self Assembly of GeO₂ Nanoparticles: A Biomimetic Approach

Creator:: Gessford, Makayla SueAnn Fu Ting
Abstract:: Diatoms are single celled eukaryotic microalgae that self-assemble complex SiO₂ nanostructures by sillafin proteins within their cell wall. There has been increasing interest in mimicking the diatom’s silica self-assembly process for fabricating metal oxide nanoparticles, namely germanium dioxide (GeO₂). GeO₂ has a higher refractive index than silica, enabling it to...
Resource Type:: Honors College Thesis
Full Text:: THESIS OF Makayla SueAnn Fu Ting Gessford for the degree of Honors Baccalaureate of Science in

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Creator:: Patel, Karan A.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Resource Type:: Honors College Thesis
Full Text:: regulation will be evaluated in lung tissue from adult offspring exposed in utero to sulforaphane

Gene regulatory mechanisms of the lncRNA Fendrr

Creator:: Koehler, Monika
Abstract:: Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: involved in gene regulation through triplex interactions with genomic DNA  Focused on the lung derived

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis
Full Text:: in the lung after exposure to inhaled pollutants; however, little is known about specific

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Creator:: Luker, George W.
Abstract:: There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
Resource Type:: Presentation
Full Text:: of DNA-Adducts implicated in lung cancer •How do we identify the carcinogenic potential? Zhang

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: response to BAP, cigarette smoke, and pollution-related lung diseases and cancers. The 3D HBEC model

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: (Chang et al., 2013). A prevalent CYP1B1 SNP associated with increased cancer incidence is the CYP1B1*3

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Creator:: Luker, Sabrina R.
Abstract:: In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Resource Type:: Undergraduate Thesis
Full Text:: , 40 kHz 450 1000 Yes MQ (Zhu, Chang, & Chen, 2010) Al2O3 ultrasonicator (Sonics, USA

ScholarsArchive@OSU

Impact of Polycyclic Aromatic Hydrocarbons on Barrier Function Toxicity in 3D Lung Model from Normal and Asthmatic Donor Cells

Field-use electrochemical sensors for detection of carbamazepine in saliva and water

Self Assembly of GeO₂ Nanoparticles: A Biomimetic Approach

Sulforaphane Regulation of LncRNA in a Transplacental Nrf2 Knockout Mouse Model Exposed to Dibenzo[def,p]chrysene

Gene regulatory mechanisms of the lncRNA Fendrr

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

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