• Bladder Cancer in the United States has
progressively been one of the more common
cancers and is estimated to have 74,000 new
cases as well as 16,000 deaths in 2015.1
• This type of cancer also has one of the highest
rates of recurrence with an average of 60%...
Circadian regulation is essential for many physiological functions, from sleep/wake patterns to hormonal rhythms. While the brain’s biological clock, the suprachiasmatic nucleus (SCN), likely plays a role in reproductive rhythms, it remains unknown if intracellular circadian clocks elsewhere contribute to the neuroendocrine control of reproduction. Gonadotropin-releasing hormone (GnRH) stimulates pituitary...
Aquatic animals possess surprising similarities to humans in reproductive signaling that are simplified or elaborated for life underwater, making them useful for studying reproductive control. In this thesis, killifish and sea anemones are used as models for reproductive function and aging. The aging model Nothobranchius (killifish) was used to investigate...
Canine transitional cell carcinoma (TCC) has been shown to have a substantial inflammatory component. It exhibits genotypic and morphologic elements that resemble its human counterpart. Cyclooxygenases (COX) are key enzymes in the synthesis of proinflammatory molecules, such as prostaglandins. Excess prostaglandin production through cyclooxygenases may promote oncogenesis and progression of...