Index Catalog // ScholarsArchive@OSU

Addressing ALS: Corroborating the Methodology of Studying the P2X7R Complex

Creator:: Veytsman, Edward Y.
Abstract:: Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex and spinal cord. Recent evidence suggests that the purine receptor P2X7 (P2X7R) plays a central role in the pathology of ALS. Previous research indicates that P2X7R activation by oxidatively modified heat shock protein 90...
Resource Type:: Honors College Thesis
Full Text:: was used to make a DMEM mixture with 10 μg/mL polybrene. The frozen virus was thawed at 37oC

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Creator:: Sy, Kevin
Abstract:: Although it is the first drug approved for usage to treat amyotrophic lateral sclerosis (ALS), riluzole’s mechanism of action is unknown and its therapeutic quality is hampered by its relatively short window of effectiveness. P2X7 is a purine receptor found in astrocytes and other cells, which increases calcium concentrations within...
Resource Type:: Honors College Thesis
Full Text:: c-Myc-hEAAT2, EAAT2 levels rose slightly over the course of the disease, rather than decreasing

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Creator:: Merschel, Andrew G.
Abstract:: Old-growth dry-mixed conifer forests are valued as habitats for late seral forest species, for the ecosystem services and landscape diversity they provide, and for their aesthetic appeal. The structure of these forests has been heavily altered by historic logging of overstory ponderosa pine and Douglas-fir. Additionally, changes in fire regime...
Resource Type:: Honors College Thesis
Full Text:: THE THESIS OF Andrew G. Merschel for the degree of Honors Baccalaureate of Science in Natural

Expression of Phospholipase C-beta Isoenzyme in Embryonic Mice

Creator:: Jong, Anita M., Filtz, Theresa, and Kioussi, Chrissa
Abstract:: Phospholipase C enzymes hydrolyze the rare membrane lipids phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2) PIP into inositol triphosphate (IP3) and diacylglycerol (DAG). Phospholipase C enzymes of the β subtype (PLC-β) function specifically in the signal transduction pathways regulated by Gαq-coupled seven transmembrane receptors. These signaling pathways link plasma membrane receptor activation...
Resource Type:: Poster

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis
Full Text:: Susan C. Tilton There is increased emphasis on understanding cumulative risk from the combined

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Creator:: Watt, Alexander T.
Abstract:: Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
Resource Type:: Honors College Thesis
Full Text:: 1 2 3 4 CRAL-TRIO Gene E - M e a n F o ld C h a n g e (2 -  c t ) * gpx4a

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: :10.3892/mmr.2017.6595. Ma G, Jing C, Huang F, Li X, Cao X, Liu Z. 2017. Integrin α6 promotes esophageal

Role of Nitrated Hsp90 in Schwannoma Cell Survival

Creator:: Kim, Sharon R.
Abstract:: Neurofibromatosis Type 2 (NF2) is a genetic tumor disorder caused by mutations that inactivate the gene coding for the Merlin tumor suppressor. Patients with NF2 develop multiple tumors throughout the nervous system, mainly schwannomas, for which there is no cure or effective treatment. In NF2, redox signaling and oxidative stress...
Resource Type:: Honors College Thesis
Full Text:: -80 °C. A Lowry assay was performed in a 96-well microplate to quantify protein concentration. 30 μg

High-resolution infrared studies of perdeutero-spiropentane, C₅D₈

Creator:: Erickson, Blake Alexander, Ju, X., Nibler, Joesph W., Beaudry, C. M., and Blake, T. A.
Abstract:: Perdeutero-spiropentane (C₅D₈) has been synthesized and infrared and Raman spectra are reported for the first time. Wavenumber assignments are made for most of the fundamental vibrational modes. Gas phase infrared spectra were recorded at a resolution (0.002 cm⁻¹) sufficient to resolve individual rovibrational lines and show evidence of strong Coriolis...
Resource Type:: Article
Full Text:: added over 1 hour at 0°C to a solution of LiAlD4 (Alfa, 98%D) (4.5 g, 98.9 mmol) in 200 mL ether. The

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

Creator:: Lo, Lalee C.
Abstract:: Tumor necrosis factor alpha (TNF α) and interferon gamma (IFN γ) were initially recognized as inflammatory mediators produced by immune cells in response to infectious agents or foreign material. (1,5) However, over the past decade much research in mammalian species has indicated that these proteins also play key roles in...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: and Uninfected Zebrafish By Lalee C. Lo An Undergraduate Thesis Submitted to Oregon State

ScholarsArchive@OSU

Addressing ALS: Corroborating the Methodology of Studying the P2X7R Complex

The Effect of Riluzole on P2X7 and EAAT2 Expression by Inducible Neural Progenitor Cell (iNPC)-derived Astrocytes

Stand Structure of Old Growth Dry Mixed Conifer Forests in the Deschutes and Ochoco National Forests

Expression of Phospholipase C-beta Isoenzyme in Embryonic Mice

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Impact of Vitamin E Deficiency on Hepatic Gene Expression of CRAL_TRIO Family Proteins in a Premier Vertebrate Animal Model

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Role of Nitrated Hsp90 in Schwannoma Cell Survival

High-resolution infrared studies of perdeutero-spiropentane, C₅D₈

Immunohistochemistry Studies of Tumor Necrosis Factor Αlpha and Interferon Gamma Expression in Pseudocapillaria tomentosa Infected and Uninfected Zebrafish

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