Index Catalog // ScholarsArchive@OSU

Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

Creator:: Smith, Natasha M.
Abstract:: In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
Resource Type:: Honors College Thesis
Full Text:: -Strand Displacement microRNA Biosensors By: Natasha Smith A project submitted to

Characterization of Mitochondrial Metabolism in L6 Rat Myoblasts

Creator:: Burney, Emily R.
Abstract:: The prevalence of obesity is increasing worldwide, causing a subsequent increase in insulin resistance (IR), metabolic disorders, and cardiovascular diseases. Although these conditions significantly impact both the individual and society, their etiologies have not been discovered, inhibiting potential prevention and treatment. Alterations to mitochondrial metabolism are implicated in the development...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing Biological and Population Health Sciences

Second Derivative Excitation Emission Resolution (SEC DEER) Spectroscopy

Creator:: Rosene, Benjamin L.
Abstract:: Fluorescence spectroscopy is a powerful analytical technique due to bright signals that provide excellent measurement sensitivity. Many colors of fluorescent dyes are available to match the detection ranges of different equipments. Dyes can be chemically modified to bind to many different target analytes with high specificity1. Alternatively, sensors can be...
Resource Type:: Honors College Thesis
Full Text:: Spectroscopy Abstract approved:_____________________________________________________ Sean M

Characterization of the Cellular Respiration and Mitochondrial Metabolism in C2C12 Mouse Myoblasts

Creator:: Sather, Bergen K.
Abstract:: Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is skeletal muscle insulin resistance (IR) and is often associated with obesity. Despite decades of study, the mechanisms of IR have not been fully resolved. Evidence has implicated mitochondrial dysfunction as a potential cause and/or consequence of IR....
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Sean Newsom Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is

Regulation of muscle fat oxidation and storage by ACSL enzymes and effects of acute exercise training in humans

Creator:: Boechler, Victoria
Abstract:: The increase in obesity rates in both children and adults in the United States may be a result of impaired or dysregulation of fat metabolism. Long chain acyl-CoA synthetases (ACSLs) may be key regulators of skeletal muscle cell fat metabolism, including fat oxidation and storage. The purpose of the study...
Resource Type:: Honors College Thesis
Full Text:: humans . Abstract approved:_____________________________________________________ Sean

Synthesis and SERS : Reproducible Nanostar Plasmons and a Study of Optical Enhancement

Creator:: Ramsey, Jacob D.
Abstract:: Gold nanostars are a relative newcomer to the nanoparticle scene, and their unique properties make them very desirable for spectroscopic applications. These nanoparticles, with their sharp tips, create electric field enhancements that interact with light in an advantageous way. This Thesis outlines our in-depth study of gold nanostar synthesis, the...
Resource Type:: Honors College Thesis
Full Text:: : ______________________________________________________ Sean M. Burrows Gold nanostars are a relative newcomer to the nanoparticle scene, and

Improving Bioanalytical Methods of miRNA Analysis and its Applications to Breast Cancer

Creator:: Tran, Victoria
Abstract:: Micro-ribonucleic acids (miRNA) are becoming an increasingly popular topic of research in hopes of discovering newfound biomarkers and/or therapies for numerous types of cancers and diseases. MiRNA are a type of biomolecule contributing to the progression of multiple cancers and diseases, and such biomolecules are called biomarkers. Current RNA-based biosensors...
Resource Type:: Honors College Thesis
Full Text:: : ________________________________________________________________________ Sean M. Burrows Micro-ribonucleic acids (miRNA) are becoming an increasingly popular

Salvage operations on the Smith River burn

Creator:: Moore, Spencer T.
Resource Type:: Undergraduate Thesis
Full Text:: Salvage operations on the Smith River burn SALVAGE

Short-Term Lipid Overload in Skeletal Muscle Induces Mild Mitochondrial Membrane Depolarization as a Stimulus for Autophagy Activation

Creator:: Brinck, Isabel M.
Abstract:: Type 2 Diabetes Mellitus is a chronic metabolic condition that impairs insulin stimulated glucose absorption in skeletal muscle, a characteristic phenomenon denoted as insulin resistance. Lipid overload of the mitochondria is linked to the development of insulin resistance and the progression of Type 2 Diabetes. As lipids accumulate there is...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Sean Newsom, Committee Member, representing the School of Biological and Population Health

Germans and the Union: Immigrants' Struggle Against Assimilation in the Civil War Era

Creator:: Diebel, Nathan W.
Abstract:: The United States of America is founded upon immigration, and Germans are one of the first European ethnic groups to settle en masse in North America. The common narrative of immigration is that of the “melting pot”; characterized by assimilation of cultures into one ‘super’ culture. German immigration has often...
Resource Type:: Honors College Thesis
Full Text:: Against Assimilation in the Civil War Era by Nathan W. Diebel A THESIS

ScholarsArchive@OSU

Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

Characterization of Mitochondrial Metabolism in L6 Rat Myoblasts

Second Derivative Excitation Emission Resolution (SEC DEER) Spectroscopy

Characterization of the Cellular Respiration and Mitochondrial Metabolism in C2C12 Mouse Myoblasts

Regulation of muscle fat oxidation and storage by ACSL enzymes and effects of acute exercise training in humans

Synthesis and SERS : Reproducible Nanostar Plasmons and a Study of Optical Enhancement

Improving Bioanalytical Methods of miRNA Analysis and its Applications to Breast Cancer

Salvage operations on the Smith River burn

Short-Term Lipid Overload in Skeletal Muscle Induces Mild Mitochondrial Membrane Depolarization as a Stimulus for Autophagy Activation

Germans and the Union: Immigrants' Struggle Against Assimilation in the Civil War Era

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