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Machine learning approach to improve drug discovery in natural product extracts

Creator:: Heussner, Robert T.
Abstract:: Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
Resource Type:: Honors College Thesis
Full Text:: his expertise, guidance, and patience over the last two years. I would like to thank Fred Stevens

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

Creator:: Moreno Luna, Arlyn Y.
Abstract:: 2014 Library Undergraduate Research Award winner
Resource Type:: Honors College Thesis
Full Text:: sincere thank you to: leeCole L Legette, Cristobal L Miranda, and J. Fred Stevens !~~;f~~~~~~~§~~~~i

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Creator:: Bratton, Daniel
Abstract:: The oilseed crop Limnanthes alba (white meadowfoam) is grown in Oregon. Methods were developed for the production of a liquid-based bioherbicide from meadowfoam seed meal (MSM). It was determined that glucosinolate-containing extracts of MSM can be combined with active-enzyme-containing liquid extracts of meadowfoam seed to form a fermented product rich...
Resource Type:: Undergraduate Thesis
Full Text:: : ____________________________________________________ Dr. Jan F. Stevens, Primary mentor

Women's History Lessons for High School Social Studies Classes

Creator:: Mallery, Adah E.
Abstract:: Women’s history is often not included in K-12 classes. However, women are an essential part of American history and should be better represented in the K-12 curricula and classrooms. The purpose of this thesis is to both acknowledge that women’s history is often missing in K-12 classrooms and to provide...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Steven Shay, Committee Member, representing School of History, Philosophy, and Religion

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:: Sanchez, Karina M.
Abstract:: Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...
Resource Type:: Undergraduate Thesis
Full Text:: (NIFA) which is part of the US Department of Agriculture (USDA) and Dr. Fred Stevens’ OSU College of

Using Mass Spectrometry to Trace Polyphenols in Human Urine

Creator:: Carrillo, Crystal V.
Abstract:: Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: thanks to Fred Stevens, Jaewoo Choi, Sandra Uesegui, Rachel Hahn, and Gerd Bobe for aiding in proper

Aging and oxidative damage to mitochondrial membrane proteins

Creator:: Tong, Tony T.
Abstract:: Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Resource Type:: Honors College Thesis
Full Text:: ACKNOWLEDGEMENT First of all, I would like to thank my mentors, Dr. Claudia Maier and Dr. Fred Stevens for the

Comparative lipid profiling of human stratum corneum between atopic dermatitis and healthy subjects

Creator:: Stewart, Shelby L.
Abstract:: Dermatological issues are a widespread problem in humans that are often overlooked. In our present study, we have isolated lipids from de-identified epidermal skin tape samples from both Atopic Dermatitis and healthy individuals using a high efficiency one-step extraction method, which were subsequently analyzed using modified Liquid chromatography–mass spectrometry (LC-MS)....
Resource Type:: Honors College Thesis
Full Text:: with a triple quadruple system in collaboration with Jaewoo choi and Dr. Fred Stevens of the Linus

Keeping Oregon green : handbook for field men of the Keep Oregon Green Association

Creator:: McNulty, Eugene
Resource Type:: Undergraduate Thesis
Full Text:: professor of wood products, O.S.C. Special thanks are also due Fred M. Shideler, head of the O.S.C

Winter sports of the northwest

Creator:: Johnson, Walter R.
Resource Type:: Undergraduate Thesis

ScholarsArchive@OSU

Machine learning approach to improve drug discovery in natural product extracts

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

Enzyme-Mediated Conversion of Glucolimnanthin to Bioherbicidal Breakdown Products

Women's History Lessons for High School Social Studies Classes

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Using Mass Spectrometry to Trace Polyphenols in Human Urine

Aging and oxidative damage to mitochondrial membrane proteins

Comparative lipid profiling of human stratum corneum between atopic dermatitis and healthy subjects

Keeping Oregon green : handbook for field men of the Keep Oregon Green Association

Winter sports of the northwest

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