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  • Synchronized Cellular Mechanosensing due to External Periodic Driving

    Creator:
    Chase, Katelyn J.
    Abstract:
    The response of cells to periodic driving is important for many biological processes, particularly blood flow and heart functioning. Our research analyzes the collective shear stress response of fibroblast cells due to a periodic driving frequency. When cells experience shear stress, they release calcium into the cytosol. To quantify the...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    Driving Katelyn Chase Advisor: Dr. Bo Sun A Thesis presented for the degree of Bachelor of Science

  • Cancer Cell Detection with Mask R-CNN

    Creator:
    Wong, Ryan
    Abstract:
    Instance segmentation, the classification and localization of objects in an image, is a problem in cellular biophysics due to the physiological relevance of cell morphology. Particularly, cancer cells migrate in tissue space by changing their body shape similarly to how humans extend their limbs to swim through water. Monitoring such...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Girshick, and J. Sun. Faster r-cnn: Towards real-time object detection with region proposal networks. ArXiv

  • Framework for Computational Modelling of Cellular Diffusion Systems

    Creator:
    Senger, Mitchell John
    Abstract:
    Many biological processes are regulated by the presence and movement of cellular Ca²⁺ ions. The concentration of Ca²⁺ in a cellular environment is regulated by IP₃ sensitive channels that lie on the surface of a cell’s endoplasmic reticulum. Little is known about the macroscopic effects of intracellular Ca²⁺ activity, so...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    Diffusion Systems Thesis by Mitchell John Senger Advised By Dr. Bo Sun 8 May 2015 Oregon State

  • Look Ma, no beads: Analyzing traction force characteristics of migratory adenocarcinoma in heterogeneous type-1 collagen through bead-free confocal microscopy

    Creator:
    Groves, Nicholas Scott
    Abstract:
    Current methods in traction force analysis rely on a homogeneous extra-cellular matrix and embedded microbeads to track deformations. The efficacy of these methods decreases when the matrix is not homogeneous. In heterogeneous matrices, beads often aggregate in regions of higher matrix density and float in regions where matrix substrate is...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    confocal microscopy Nicholas Scott Groves Advisor: Prof. Bo Sun May 30, 2016 1 Abstract Current

  • State-of-the-Art Combination Therapies and Nanomedicines for Triple Negative Breast Cancer

    Creator:
    Fabbi, Meagan C.
    Abstract:
    Triple-negative breast cancer (TNBC) is a particularly aggressive molecular subtype of malignant cells that tends to proliferate quickly and is commonly resistant to traditional chemotherapy leading to relapses in prognosis more frequently than other forms of breast cancer (BCa) [1][2][3]. Current treatment options include surgical resection of cancerous tissue and...
    Resource Type:
    Honors College Thesis
    Full Text:
    Cancer Abstract approved: _______________________________________________________ Conroy Sun

  • Directing Cell Migration via Environmental Anisotropy

    Creator:
    Sheetz, Justin
    Abstract:
    Type I collagen fibers, the connective tissue that makes up the human breast, can be easily manipulated by cells or other outside factors. In previous studies, the alignment of collagen has been associated with the beginning of metastatic cancer, possibly influencing cancerous cells to migrate from the tumor. In this...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    Justin Sheetz An undergraduate thesis advised by Associate Professor Bo Sun submitted to the

  • Formation and Migration of Breast Cancer Spheroids

    Creator:
    Hurley, Casey M.
    Abstract:
    Invasive breast cancer affects 1 in 8 women during their lifetime. Current cancer research uses 2-D cell culturing, which does not accurately represent tumor behavior. In comparison to tumors, cells grown using 2-D cell culturing have different proliferation and diffusion rates, cell shapes, and gene expression. To improve in vitro...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: _____________________________________________________ Bo Sun Invasive

  • Comparison of a Persistent Random Walk to 3D Chemo taxis in MDA-MB-231 Cancer Cells

    Creator:
    Thayer-Freeman, Cameron
    Abstract:
    This research specifically examines the collective motion of populations of MDA-MB-231 breast cancer cells under the influence of a chemo-attractant gradient. Their motion is compared to the mathematical model of a persistent random walk, measuring the persistence bias of the cells from their autocorrelation function and applying to the mean...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    , G., Sun B., Leed J., Wue A, Kamf Y, Sontagg ED, Stonec HA, Sturme JC, Gatenby RA, Austin RH

  • A quantitative analysis of three-dimensional contact guidance by breast cancer cells

    Creator:
    Krnacik, Emma A.
    Abstract:
    Exploring and quantifying the parameters regarding contact guidance may provide valuable insight to the precise mechanisms controlling cell movement, especially in a three-dimensional environment. The objective of this project was to quantify the relationship between MDA-MB-231 cell morphogenesis and the geometry of the cell’s local microenvironment, which was modeled by...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _____________________________________________________ Bo Sun Exploring and quantifying the parameters regarding contact guidance may provide

  • A novel method for detecting lines on a noisy image

    Creator:
    Lin, Daniel
    Abstract:
    We developed an integration-based line detection algorithm. Existing line detection methods such as the Hough Transformation (HT) and its variants are insensitive to image noise. The reason is that HT finds lines by calculating the gradient of the image and assumes that the region where the gradient is the steepest...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    Physics Oregon State University Supervisor: Dr. Bo Sun May 2015 Contents List of Figures 3 1