Pseudomonas syringae is a Gram-negative bacterium that can infect a variety of important crops. Infection by P. syringae is dependent on a type III secretion system (T3SS) that delivers effector proteins to plant cells to suppress host defenses. Previous work has shown that, in the presence of simple sugars, specific...
Post-menopausal women are at an increased risk for osteoporosis due to increased
bone resorption associated with estrogen deficiency. Subcutaneous administration of leptin, a
hormone produced primarily by adipocytes, attenuates bone loss in the ovariectomized (ovx)
rat, an animal model for post-menopausal bone loss. Leptin has both direct peripheral and
indirect...
Insoluble surfactants are unique molecules that have the ability to manipulate interfacial properties, becoming useful in numerous applications such as detergents, wetting agents, emulsifiers, foaming agents, dispersants, and more. Interfacial rheology is a field that attempts to characterize the flow properties of insoluble surfactants by exerting a stress on the...
Bone loss is common in astronauts during long-duration spaceflight missions with severe bone loss often occurring in the proximal femur, a region not typically investigated in animal models for microgravity. We recently evaluated bone microarchitecture in the femoral head in rapidly growing male Sprague Dawley rats subjected to a 4-day...
Heavy alcohol consumption reduces peak bone mass in growing rodents and can lead to bone loss in both adult rats and humans. In contrast, moderate alcohol consumption appears to have a bone sparing effect in post-menopausal women. Alcohol has been reported to increase aromatase activity and influence estrogen receptor (ER)...
Severe cases of COVID-19 have been associated with cytokine storms, leading to widespread inflammation, tissue damage, and organ failure. Pro-inflammatory cytokines have also been shown to play a role in liver diseases, including alcoholic liver disease. To investigate alcohol consumption as a risk factor for SARS-CoV-2 infections and COVID-19 severity,...
Cisplatin (CDDP) is a highly active platinum-containing chemotherapeutic agent for use against solid tumors, including ovarian. However, like most antitumor agents, CDDP use is accompanied by non-tumor tissue toxicities leading to unwanted side effects, including neuropathy. To date, the mechanism(s) for these side effects are undefined. However, the clinical features...
The Min protein system in Escherichia coli helps the cell division process by identifying the center of the cell [1, 7]. This system has been modeled succesfully computationally under standard conditions. There has been recent experimental interest in the cell division process for significantly perturbed cell shapes. We take the...