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Filtering by: Creator Bretherton, Christopher S. Remove constraint Creator: Bretherton, Christopher S. Degree Level Doctoral Remove constraint Degree Level: Doctoral File Format application/pdf Remove constraint File Format: application/pdf

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  • Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

    Creator:
    Stoner, Christopher S.
    Abstract:
    Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Christopher S. Stoner for the degree of Doctor of Philosophy in

  • Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

    Creator:
    Shen, Rongkun
    Abstract:
    The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
    Resource Type:
    Dissertation
    Full Text:
    Synthetase Complex Abstract approved: Christopher K. Mathews The

  • Indirect effects of fishing on predators and their prey

    Creator:
    Stallings, Christopher Derek
    Abstract:
    Predators are fundamentally important for regulating and driving prey population dynamics as well as structuring ecological communities. Over-exploitation of marine resources has caused dramatic depletions of predatory fish species and shifts in marine community composition, with attendant declines in productivity and diversity of marine ecosystems. Despite the important ramifications of...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Christopher D. Stallings for the degree of Doctor of

  • Ecological subsidies to rocky shore communities : setting the stage for community dynamics in the Northeast Pacific

    Creator:
    Krenz, Christopher
    Abstract:
    This dissertation focuses on the importance of pelagic subsidies in the Northeast Pacific to rocky shore community regulation. My results document the patterns of pelagic subsidy supply, determine if those subsidies are correlated with community structure, and examine if community regulation differs between areas of high- and low-subsidies. Understanding how...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Christopher Krenz for the degree of Doctor of Philosophy in Zoology presented on January

  • Quantifying linear disturbance growth in periodic and aperiodic systems

    Creator:
    Wolfe, Christopher Lee
    Abstract:
    The mathematical and physical connections between three different ways of quantifying linear predictability in geophysical fluid systems are studied in a series of analytical and numerical models. Normal modes, as they are traditionally formulated in the instabilities theories of geophysical fluid dynamics, characterize the asymptotic development of disturbances to stationary...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Christopher L. Wolfe for the degree of

  • Measuring innovativeness in the North American softwood sawmilling industry

    Creator:
    Knowles, Christopher David
    Abstract:
    Innovativeness, or the propensity of a firm to create and/or adopt new products, process and business systems, has been measured using several methods in previous research. Examples of theses methods include current technology, self-evaluation, research and development funding, the number of new products, and intellectual property. In addition to the...
    Resource Type:
    Dissertation
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    Christopher David Knowles of the degree of Doctor of Philosophy in Wood Science presented on March 9, 2007

  • Mantle melting and heterogeneity along mid-ocean ridges : insight from basalt geochemistry along axial depth and morphologic gradients for intermediate spreading rate systems

    Creator:
    Russo, Christopher J.
    Abstract:
    This investigation focuses on gaining a better understanding of the complex relationship between melt generation, source variability and mid-ocean ridge morphology. The approach adopted here uses a variety of geochemical techniques to evaluate the ability of 'global' models to predict regional scale geochemical variability associated with axial depth and axial...
    Resource Type:
    Dissertation
    Full Text:
    1980’s, as ridge systems in the Atlantic, Pacific and Indian Oceans became more densely sampled, the

  • The detection of superoxide and implications for amyotrophic lateral sclerosis

    Creator:
    Robinson, Kristine M.
    Abstract:
    Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
    Resource Type:
    Dissertation
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    : ______________________________________________________________ Joseph S. Beckman Mutations to superoxide dismutase were the first proven cause of Lou

  • Remote measurements of waves and currents over complex bathymetry

    Creator:
    Chickadel, Carmine C. (Carmine Christopher)
    Abstract:
    Waves are the primary input of energy in the nearshore region, and together with the currents forced through the transfer of momentum that occurs during the wave breaking process they are the principal mechanism for sediment transport in the nearshore. The basic physics of waves and currents are thought to...
    Resource Type:
    Dissertation
    Full Text:
    error 0.38 m/s). Though cases of two-dimensional circulation (i.e. rip currents) are shown to

  • Mechanisms for the interaction of environmental mycobacteria with host cells

    Creator:
    Harriff, Melanie J.
    Abstract:
    Environmental mycobacteria are important opportunistic pathogens for many hosts, including humans, cattle, and fish. Two well-studied species are Mycobacterium avium subsp. avium, a significant cause of disseminated bacterial disease in patients with AIDS, and Mycobacterium avium subsp. paratuberculosis, the cause of Johne’s disease in cattle. Many other species that are...
    Resource Type:
    Dissertation
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    . Bermudez, L. E., and L. S. Young. 1994. Factors affecting invasion of HT-29 and HEp-2 epithelial cells by