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Filtering by: Alternative title ssim EC 908 Degree Level Doctoral Subject Antineoplastic agents

Investigation of unique marine environments for microbial natural products

Creator:

Thornburg, Christopher C.

Abstract:

Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...

Resource Type:

Dissertation

Full Text:

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Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:

Hoyt, Dale G.

Abstract:

Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...

Resource Type:

Dissertation