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Filtering by: Alternative title ssim Report no. 1125 Remove constraint Alternative title ssim: Report no. 1125 Degree Level Doctoral Remove constraint Degree Level: Doctoral Subject DNA Remove constraint Subject: DNA

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  • DNA based artificial nanostructures : directed assembly of cellulose nanocrystals into advanced nanomaterials

    Creator:
    Mangalam, Anand Paul
    Abstract:
    The fabrication of nano-scale devices is a challenging, but potentially important, technology that has drawn a great deal of interest among researchers. Such nanoscale constructions utilizing a bottom-up approach for device building have many foreseeable applications in areas as diverse as miniaturized electronics, sensors, and biomedical devices. One of the...
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    characterize the morphology of the dried dispersion. To our knowledge, this is the first report of DNA

  • Alternatives to the DNA precursor-synthesizing enzyme complex hypothesis

    Creator:
    Weitz, Stephen L.
    Abstract:
    Investigators have been studying an aggregate containing enzymes of deoxyribonucleoside triphosphate biosynthesis in T4-phage infected bacteria. They suggest that it behaves as an organized complex, efficiently channeling DNA precursors to the replication apparatus. Previous work has suggested that about 10 enzyme activities remain associated through several fractionation steps. This multi-enzyme...
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    multistep pathways with virtually no lag and with low accumulation of intermediates. However, work

  • The association of DNA with other cellular materials in Escherichia coli lysates

    Creator:
    Porter, Bruce Wallace
    Abstract:
    The association of other materials with DNA has been studied extensively in higher organisms and more recently in bacteria. However, investigation of these complexes in bacteria have for the most part been restricted to the study of a specific function this association may serve, or a specific kind of association....
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    Dissertation
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    acidic proteins are found con- nected with DNA but that the nature of binding may differ. There is no

  • Site-specific aflatoxin B₁ adduction of sequence-positioned nucleosome core particles

    Creator:
    Moyer, Richard A.
    Abstract:
    The question of how the presence of nucleosomal packing of DNA modifies carcinogen interaction at specific sites cannot be answered by studies on whole chromatin or bulk nucleosomes because of the heterogeneity of DNA sequences in the particles. This problem was circumvented by constructing nucleosomes that are homogenous in DNA-histone...
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    AFB1-C12 adduction in regions near the particle boundary. I observe no other histone-imposed

  • Properties and conformation of P-form DNA

    Creator:
    Zehfus, Micheal H.
    Abstract:
    Work is presented which explores the properties and nature of the P-form of DNA. Initially the P-form represented an unknown state of DNA which occurred when this molecule was in a solvent of 47.5% methanol, 5% water, and 47.5% ethanol, and which showed properties of both native and denatured conformations....
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    , and then proved when infrared spectroscopy shows that there is no hydrogen bonding in the P-form

  • A partial characterization of the deoxyribonucleic acid found in the thoracic muscles of the tobacco hornworm moth (Manducta sexta)

    Creator:
    Hinds, Thomas Richard, 1944-
    Abstract:
    The DNAs (deoxyribonucleic acids) of the thoracic tissue of the tobacco hornworm, Manducta sexta, were studied by physical and chemical means. The adult moth was considered to be fully formed two days after emergence from the pupal case, as indicated by its ability to fly and the integrity of the...
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    moths stored for 3 days at 4° C show no visible signs of deterioration. Upon warming to room temperature

  • Studies on the hydrophobic effect and its contribution to the stability, crystallization, and helix packing of Z-DNA

    Creator:
    Kagawa, Todd F.
    Abstract:
    The studies presented here use the B- to Z-DNA transition and Z-DNA crystallization as model systems to determine the contribution of solvent interactions to macromolecular structures. The substituent groups of naturally occurring and modified nucleotide bases affect the hydration and thus the stability of right-handed B-DNA and left-handed Z-DNA. The...
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    for 5 sequences where there was effectively no differences in steric interactions for the two

  • Hydrodynamic properties of homogeneous double-stranded DNA

    Creator:
    Kovacic, Roger Timothy
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    Dissertation
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    conformation in solution. There was no concentration or speed effect observed for the largest fragment over a

  • Crystal structures of DNA four-way junctions

    Creator:
    Eichman, Brandt F.
    Abstract:
    DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
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    (41.8) d/cr[> (J 10.6 (2.7) 12.8 (3.1) Refinement 0 Resolution Range (A) 8-2.10 10-2.50 No. of

  • Studies on the interaction of polylysine with deoxyribonucleic acid

    Creator:
    McKenzie, Raymond Leslie
    Abstract:
    The interaction of polylysine with DNA may be divided into two separate phenomena: the primary interaction involved in formation of a well-defined complex, and secondary interactions leading to aggregation of these complexes. Most studies on the interaction of polylysine with DNA have used techniques which measure properties of the aggregated...
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    , suggest the lysine-rich histone may be rather heterogeneous and report they exhibit phenotypic