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Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

Creator:: Pang, Qishen
Resource Type:: Dissertation
Full Text:: DNA clones of Arabidopsis actin gene and chalcone synthase gene, respectively. Many thanks to

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Creator:: Wilcox, Buck W. L.
Abstract:: Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops for use in breeding and trait development. Errors that occur during DNA replication may cause mutations if they are not corrected...
Resource Type:: Dissertation
Full Text:: somatic mutations, or they require insertion of a different reporter gene construct into the plants

Characterization of Escherichia coli double-strand uracil-DNA glycosylase and analysis of uracil-initiated base excision DNA repair

Creator:: Sung, Jung-Suk
Abstract:: Escherichia coli double-strand uracil-DNA glycosylase (Dug) was purified to apparent homogeneity from bacteria that were defective in uracil-DNA glycosylase (Ung). After cloning the dug gene, recombinant Dug was overexpressed, purified, and characterized with respect to activity, substrate specificity, product DNA binding, and mechanism of action. Purified Dug excised both uracil...
Resource Type:: Dissertation
Full Text:: homogeneity from bacteria that were defective in uracil-DNA glycosylase (Ung). After cloning the dug gene

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Creator:: Shin-Darlak, Chi Y.
Abstract:: DNA damage, if not repaired, can become a mutation. Mutation accumulation is associated with initiation and progression of tumorigenesis. DNA mismatch repair (MMR) is required for maintaining genetic stability by repairing replication errors. Biochemical studies have shown that MMR also recognizes mismatch-causing DNA lesions, suggesting the role of MMR in...
Resource Type:: Dissertation
Full Text:: using the 2.3 Kb mouse Aprt gene in kidney cells of PMS2 or MLH1 null mice. I report that loss of MLH1

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Creator:: Culligan, Kevin M.
Resource Type:: Dissertation
Full Text:: . DNA Mismatch Repair in Plants: An Arabidopsis thaliana Gene that Predicts a Protein Belonging to the

Uracil-DNA glycosylase inhibitor protein : role of carboxylic acid residues and use for measuring the fidelity of uracil-excision DNA repair synthesis in human cell extracts

Creator:: Sanderson, Russell J.
Resource Type:: Dissertation
Full Text:: Analysis 94 2.2.17 Site-Directed Mutagenesis of the M13mp2 lacZa Gene 95 2.2.18 Preparation of Base

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:: Smith-Roe, Stephanie L.
Abstract:: The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
Resource Type:: Dissertation
Full Text:: human homologs of MMR genes. Homology searches of the human genome using yeast gene sequences lead to

Recombinagenic and anti-mutagenic processing of UV-light photoproducts by the Escherichia coli methyl-directed mismatch-repair system

Creator:: Feng, Wen-yang
Resource Type:: Dissertation
Full Text:: (Thomas et al. 1986). The major components of the UvrABC system are encoded by the uvrA, uvrB, and uvrC

The function of zinc in the maintenance of DNA integrity in vivo

Creator:: Song, Yang
Abstract:: Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...
Resource Type:: Dissertation
Full Text:: .. ...........................................................................................58 3.2 Effects of marginal zinc depletion on (A, B) gene expressions and (C, D) proteins levels of

ScholarsArchive@OSU

Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Characterization of Escherichia coli double-strand uracil-DNA glycosylase and analysis of uracil-initiated base excision DNA repair

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Uracil-DNA glycosylase inhibitor protein : role of carboxylic acid residues and use for measuring the fidelity of uracil-excision DNA repair synthesis in human cell extracts

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Recombinagenic and anti-mutagenic processing of UV-light photoproducts by the Escherichia coli methyl-directed mismatch-repair system

The function of zinc in the maintenance of DNA integrity in vivo

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